The effect of prolonged and repeated moderate-intensity exercise on inflammation in patients with Inflammatory Bowel Disease.

Completed

• Conditions: chronic inflammation of the colon; inflammatory bowel disease; 10017969

• Registration Number: NL-OMON48058
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-12-17
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 38

Inclusion Criteria

- 18 years of age or older (all participants)
- Diagnosis of Crohn*s disease or ulcerative colitis (total or left-sided
colitis) made by gastroenterologist (IBD participants)
- Participation in Nijmegen Four Day Marches, edition 2019 (all participants)

Exclusion Criteria

- Use of biologicals (e.g. infliximab, adalimumab, golumimab, ustekinumab) (IBD
participants)
- History of IBD or other gastro-intestinal diseases such as celiac disease or
Irritable Bowel Syndrome (IBS) (healthy participants)
- History of significant systemic diseases, such as diabetes mellitus, cancer,
cardiovascular or respiratory disease, that may have an effect on study
outcomes (healthy participants)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the change in gastrointestinal inflammation<br /><br>measured by faecal calprotectin in the IBD subjects.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters are inflammatory markers in blood and clinical disease<br /><br>activity measured by Harvey Bradshaw Index (HBI) in Crohn*s Disease and the<br /><br>Simple Clinical Colitis Activity Index (SCCAI) in ulcerative colitis.</p><br>