Sleep and Creativity
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Change in creativity performance prior- and post-TMS
研究概览
简要总结
Creativity is a complex neuro-psycho-philosophical phenomenon that is difficult to define. Neurocognitive models of creativity suggest that creativity is associated with the activity of a distributed, bilateral fronto-temporal and parietal network. Therefore, a modulation of frontal activity is necessary to allow a certain degree of "controlled disinhibition", which seems to be necessary for creative thinking. In addition, a modulation of the lower parietal lobe (IPL) might allow targeting the brain regions responsible for idea generation.
This project will investigate the application of transcranial magnetic stimulation (TMS) with the intent of modulating creativity performance of healthy subjects. Resting state electroencephalography (EEG) that will be acquired pre- and post-TMS and participants' creative performance will be measured.
Perspectives include a better understanding of the differences between high- and low-creativity groups, as measured by a creativity test battery, in their response to TMS. Additional perspectives are whether there are differences in creativity performance depending on the stimulation location.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Informed consent as documented by signature
- •Age between 18 and 70 years
- •Neurologically healthy, i.e., with no documented or present neurological disease or brain injury
- •Normal or corrected-to-normal visual acuity
排除标准
- •Any instable medical condition, in particular epilepsy (past or pre-sent, including seizures or febrile convulsions)
- •Any surgical intervention to the brain
- •Implanted medical devices (e.g., cochlear implants, infusion pumps, neurostimulators, pacemakers)
- •Presence of metal in the region of the head (excluding fixed dental implants such as tooth fillings or fixed dental braces)
- •Drug or alcohol abuse
- •Intake of any medication that is likely to lower seizure threshold
- •For female participants: in order to participate in the study, female patients in reproductive age need to take a pregnancy test (a stand-ard urine pregnancy test will be provided).
- •Previous enrolment in a creativity study of the same PI
研究组 & 干预措施
High-creativity
Here participants are allocated to the high-creativity group. Resting state EEG will be measured pre- and post-TMS and participants' creative performance will be measured by means of a creativity test battery.
干预措施: Transcranial Magnetic Stimulation (TMS) over the left inferior frontal gyrus (IFG) (Device)
High-creativity
Here participants are allocated to the high-creativity group. Resting state EEG will be measured pre- and post-TMS and participants' creative performance will be measured by means of a creativity test battery.
干预措施: Transcranial Magnetic Stimulation (TMS) over the left inferior parietal lobule (IPL) (Device)
Low-creativity
Here participants are allocated to the low-creativity group. Resting state EEG will be measured pre- and post-TMS and participants' creative performance will be measured by means of a creativity test battery.
干预措施: Transcranial Magnetic Stimulation (TMS) over the left inferior frontal gyrus (IFG) (Device)
Low-creativity
Here participants are allocated to the low-creativity group. Resting state EEG will be measured pre- and post-TMS and participants' creative performance will be measured by means of a creativity test battery.
干预措施: Transcranial Magnetic Stimulation (TMS) over the left inferior parietal lobule (IPL) (Device)
结局指标
主要结局
Change in creativity performance prior- and post-TMS
时间窗: 2.5 hours
Change in creativity performance (as expressed by a summary score of single tests from a creativity test battery) prior- and post-TMS in low- and high-creativity groups
次要结局
- Change in creativity performance prior- and post-TMS depending on stimulation location(2.5 hours)