Efficacy of Pentoxifylline in diabetic nephropathy
Phase 3
- Conditions
- Condition 1: Type 2 Diabetes. Condition 2: Diabetic Nephropathy.Type 2 diabetes mellitus????????? ????????N00-N08
- Registration Number
- IRCT20190806044451N2
- Lead Sponsor
- Zanjan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Type 2 diabetic patients treated with insulin and oral agents
GFR above 30 cc / min / 1.73 m2
albuminuria above 300 mg/g
Exclusion Criteria
Patient dissatisfaction
Type 1 diabetes
Pentoxifylline allergy
Chronic heart failure
Uncontrolled hypertension
Other medicines that affect albuminuria
Cerebral hemorrhage
Extensive retinal hemorrhage
ESRD, GFR <30
Pregnancy
Hyperkalemia (high potassium) 5.5 before or during the study)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Random Urin Albumin/Creatinine. Timepoint: 3 months before intervention and before starting pentoxifylline and 3 months after starting pentoxifylline. Method of measurement: Lab test.
- Secondary Outcome Measures
Name Time Method Creatinin. Timepoint: Before starting pentoxifylline and 3 months after starting pentoxifylline. Method of measurement: Lab test.;Hemoglobin A1c. Timepoint: Before starting pentoxifylline and 3 months after starting pentoxifylline. Method of measurement: Lab test.;Blood pressure. Timepoint: Before starting pentoxifylline and 3 months after starting pentoxifylline. Method of measurement: Sphygmomanometer.;Body mass index. Timepoint: Before starting pentoxifylline and 3 months after starting pentoxifylline. Method of measurement: meter & Balance.;Fasting blood sugar (FBS). Timepoint: Before starting pentoxifylline and 3 months after starting pentoxifylline. Method of measurement: Lab test.;Pentoxifylline Complications. Timepoint: Before starting pentoxifylline and 3 months after starting pentoxifylline. Method of measurement: History taking.