Myocardial injury and function in mechanically ventilated children with and without lung injury

Withdrawn

• Conditions: myocardial dysfunction; Myocardial injury; 10028593

• Registration Number: NL-OMON34967
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 75

Inclusion Criteria

Presence of biochemical evidence of myocardial injury (cardiac Troponin T and/or CK-MB and/or NT pro-BNP greater than the upper limit of the reference value)
Mechanical ventilation for at least 24 hours
Presence of indwelling central venous line
Informed consent obtained from parents or legal caretakers

Exclusion Criteria

Mechanical ventilation less than 24 hours
History of congenital heart disease
Surgery for congenital heart disease
History of acquired heart disease (i.e. cardiomyopathy, myocarditis)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Haemodynamic indices of myocardial dysfunction (cardiac index, global ejection<br /><br>fraction, dPmax).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Need for vaso-active infusions (dopamine, dobutamine, norepinephrine)</p><br>