Cardiac dysfunction in head injury patients
Not Applicable
Completed
- Conditions
- Health Condition 1: S062- Diffuse traumatic brain injuryHealth Condition 2: S063- Focal traumatic brain injuryHealth Condition 3: S066- Traumatic subarachnoid hemorrhageHealth Condition 4: S065- Traumatic subdural hemorrhage
- Registration Number
- CTRI/2021/02/031312
- Lead Sponsor
- Department of Anesthesia and Intensive Care PGIMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
1. GCS <13 presenting within 48 hrs of injury to our Hospital.
Exclusion Criteria
1. Patients above 65 or less than 18 years of age
2. Patients with significant extracranial injury (AIS more than 4)
3. Moribund patients with GCS less than 5 who are not expected to survive beyond 48 h
4. Patients with medical history of cardio-thoracic surgery or significant cardiovascular events (stroke, coronary artery disease, myocardial infarction, pacemaker, atrial fibrillation, or congestive heart disease) and patients with traumatic hemorrhagic shock.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of systolic dysfunction recorded after 72 hours of enrollmentTimepoint: after 72 hours of enrollment
- Secondary Outcome Measures
Name Time Method 30 days mortality rate in severe TBI patients with or without cardiac dysfunctionTimepoint: 30 days;�Change in Cardiac Troponin I levels from baseline on day 3 following injuryTimepoint: after 72 hrs;Changes in ECG findings from baseline on day 3 following injuryTimepoint: after 72 hrs;Correlation between NCCT findings and incidence of cardiac dysfunctionTimepoint: within 48 hrs;Incidence of baseline cardiac dysfunction following TBI (includes LV systolic and diastolic dysfunction, right ventricular (RV) dysfunction and RWMA)Timepoint: Date of admission;Incidence of late onset cardiac dysfunction (more than 48 h of injury)Timepoint: within 7 days;Time for peak recovery from LV systolic dysfunctionTimepoint: within 7 days;Time for significant recovery from LV systolic dysfunctionTimepoint: with in 7 days