Inflammatory response and cardiac muscle damage markers in pediatric cardiac surgery: effect of two cardioplegia solutions Del Nido” and blood cardioplegia”
Phase 2
- Conditions
- Tetralogy of Fallot, Congenital Heart Diseases.Ventricular septal defect with pulmonary stenosis or atresia, dextroposition of aorta and hypertrophy of right ventricle.
- Registration Number
- IRCT2016042627617N1
- Lead Sponsor
- Vice chancellor for research, ?Administrative building, Rajaei cardiovascular and medical center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
informed consent of guardians; weight below or equal to 15 kg; candidate for cardiopulmonary bypass surgery; Congenital tetralogy of Fallot; Pump time between 1 to 3 hours; operation time between 4 and 5 hours
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cardiac troponin I (cTnI). Timepoint: before operation, after declamp and 24 hours post-operarion. Method of measurement: ELISA method.;Il-6. Timepoint: Before surgery, after declamp and 24 hours post ICU entrance. Method of measurement: ELISA method on plasma.;IL-8. Timepoint: Before surgery, after declamp and 24 hours post ICU entrance. Method of measurement: ELISA method on plasma.;IL-10. Timepoint: before operation, after declamp and 24 hours post-operarion. Method of measurement: ELISA method on plasma.;TNFa. Timepoint: before operation, after declamp and 24 hours post-operarion. Method of measurement: ELISA method on plasma.;Heart rate. Timepoint: every 3 hours from operation start until 24 hours post-operation. Method of measurement: Vital sign monitoring system.;Blood pressure. Timepoint: every 3 hours from operation start until 24 hours post-operation. Method of measurement: Vital sign monitoring system.
- Secondary Outcome Measures
Name Time Method