The role of inflammation in myocardial infarction in young patients without cardiovascular risk factors: the unhappy few - a pilot study
- Conditions
- heart attackmyocardial infarction1001108210003216
- Registration Number
- NL-OMON46159
- Lead Sponsor
- RadboudUMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Cases: 20 patients aged between 18 and 50 year, who presented 1-4 years ago with an acute ST-elevation myocardial infarction without classic cardiovascular risk factors.;controls: 20 healthy controls aged 18 or above. controls will be matched with the cases for age, gender and cardiovascular risk factors.
patients:
- If the index patient has:
o Coagulation disorder
o Diagnosis of vascular disease (e.g. previous myocardial infarction, CVA, etc)
o If the index patient has two or more of the following factors present:Hypertension
o Hypercholesterolemia
o Diabetes mellitus
Active smoking or an active smoking history within the last 10 years;controles:
o Coagulation disorder
o Diagnosis of vascular disease (e.g. previous myocardial infarction, CVA, etc)
o If the index patient has two or more of the following factors present:Hypertension
o Hypercholesterolemia
o Diabetes mellitus
Active smoking or an active smoking history within the last 10 years
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Peripheral blood samples will be drawn for isolation of monocytes and<br /><br>thrombocytes. The primary endpoint are histone marks of chromatin accessibility<br /><br>such as H3K4 trimethylation (H3K4me3) and H3K9me2 in the promoter region of<br /><br>inflammatory cytokines</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary endpoints are the cytokine release by monocytes in response to<br /><br>stimulation with Toll-like Receptor(TLR)-agonists and the transformation of<br /><br>monocytes in foam cells. Also the specific blood platelet function in these<br /><br>patients will be examined. </p><br>