The effect of myocardial ischaemia on pro-inflammatory cytokines and stress proteins

Not Applicable

Completed

• Conditions: Cardiovascular: Myocardial ischaemia; Circulatory System; Myocardial ischaemia

• Registration Number: ISRCTN34742708
• Lead Sponsor: Department of Health (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2003-09-12
• Study Completion: 2009-09-10
• Last Update Posted: 24 August 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Added 24 July 2008:
Patients with greater than or equal to 1 flow-limiting coronary artery stenosis, stable symptoms & ST segment depression on exercise testing (if there is one prior to angiogram)

Exclusion Criteria

Added 24 July 2008:
Control subjects with low pre-exercise test probability of CAD & negative exercise test result (age- / sex- / body mass index- matched).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the plasma levels of interleukin-6 (IL6), tumour necrosis factor alpha (TNFa), tissue factor (TF) and heat shock protein 60 (hsp60). Two stress methods will be employed. While IL6 can also be increased with perpheral muscle stress produced by exercise, dobutamine could induce a smaller ischaemic burden. The two tests therefore will be performed in each patient in order to link cytokines to ischaemia alone.

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures