The impact of continuous haemofiltration during cardiopulmonary bypass on cardiac surgery patients with impaired renal functio

Not Applicable

Completed

• Conditions: Pre-operative renal impairment/coronary heart disease/coronary heart interventions; Urological and Genital Diseases

• Registration Number: ISRCTN48429978
• Lead Sponsor: iverpool Heart and Chest Hospital NHS Trust (UK)

Brief Summary

2015 results in https://www.ncbi.nlm.nih.gov/pubmed/26119403 (added 04/11/2019) 2019 post-hoc analysis of biomarker levels in https://www.ncbi.nlm.nih.gov/pubmed/30987577 (added 04/11/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-07-15
• Study Completion: 2013-09-01
• Last Update Posted: 10 December 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 199

Inclusion Criteria

Current information as of 26/03/10:
1. Consenting men and women aged at least 18 years old
2. High-risk patients elective for on-pump valve replacement, coronary artery bypass graft surgery (CABG) or combined CABG and valve procedures
3. Patients with impaired renal function established preoperative by an estimated glomerular filtration rate (eGFR) <50 ml/min

Initial information at time of registration:
1. Male and female patients, at least 18 years old
2. Elective for on-pump coronary artery bypass graft surgery (CABG)
3. Patients with impaired renal function established by pre-operative estimated glomerular filtration rate (eGFR) less than 60 ml/min

Exclusion Criteria

Current information as of 26/03/10:
1. Patients scheduled to undergoing cardiac surgery with anticipated CPB time <60 minutes
2. Patients undergoing surgery on the great vessels (aortic surgery)
3. Patients with significant impaired liver function (serum bilirubin > 60 or INR >2 without anticoagulation)
4. Patients who are further down the line of renal failure (i.e. eGFR <15 ml/min)
5. Patients on-dialysis
6. Presence of malignancy
7. Pregnancy

Initial information at time of registration:
1. Undergoing valve replacement surgery
2. Patients with significant impaired liver function (serum bilirubin greater than 60 or international normalised ratio [INR] greater than 2 without anticoagulation)
3. Patients on-dialysis
4. Patients that are pregnant or have malignancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Current information as of 26/03/10:<br> Length of ICU stay for non-dialysis patients with impaired kidney function (estimated glomerular filtration rate <50 ml/min)<br><br> Initial information at time of registration:<br> Incidents of ICU stay greater than 3 days for patients with eGFR less than 60 ml/min.<br>