Effect of continuous haemofiltration on essential micronutrient levels

Not Applicable

Completed

• Conditions: Acute kidney injury; Urological and Genital Diseases; Acute renal failure, unspecified

• Registration Number: ISRCTN88354940
• Lead Sponsor: Guy's & St Thomas Hospital (UK)

Brief Summary

2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30071826

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-06-10
• Study Completion: 2013-12-31
• Last Update Posted: 27 August 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Adult patients (18 years or older) in the intensive care unit with severe AKI

Exclusion Criteria

1. Pre-existing dialysis dependent renal failure
2. Life expectancy <48 hours
3. Need for total parenteral nutrition
4. Need for supplementation with intravenous multivitamins or trace elements

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Outcomes will be assessed on a daily basis for up to 6 days after enrolment.<br>Dfference in plasma concentrations of essential micronutrients between patients with and without continuous veno-venous haemofiltration (CVVH)

Secondary Outcome Measures

Name	Time	Method
1. Concentrations of trace elements, vitamins and amino acids in filtrate in patients on CVVH<br>2. Differences in filtrate losses between patients on continuous venovenous hemofiltration (CVVH) 30ml/kg/hr or less versus >30ml/kg/hr<br>3. Differences in serum levels of micronutrients and amino acids between patients on CVVH 30ml/kg/hr or less versus >30ml/kg/hr