Effect of Hesperidin on depressio

Phase 3

Recruiting

Conditions: Major Depressive Disorder.
Major depressive disorder, single episode, severe with psychotic features

Registration Number: IRCT20090901002394N41

Lead Sponsor: Iran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 48

Inclusion Criteria

Willing to participate
Clinical diagnosis of major depressive disorder; A score =15 in the 17-item Hamilton Depression Rating Scale
Age 18 – 65 years;Good health status based on medical history
No dietary supplement use during the previous two months
Not use any drugs and antidepressant
Absence of benign hormone-sensitive tumors in the ovary, uterus, breast, prostate
Not having thoughts about death and suicide
Not having any mental illness except anxiety
Do not eat citrus more than two units per day
Having physical health based on history
No regular use of any supplements more than twice a week, two months before the study

Exclusion Criteria

Pregnancy and lactation
patient's dissatisfaction to continue cooperation
Earning each non-entry criteria

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Severity of depression. Timepoint: First, middle and end of intervention. Method of measurement: Hamilton Depression Scale.;Serum level of F2 Isoprostane. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Serum level of GDNF. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Serum level of hs-CRP. Timepoint: beginning and end of intervention. Method of measurement: ELIZA.;Cognitive function. Timepoint: beginning and end of intervention. Method of measurement: D-KEFS questionnaire.

Secondary Outcome Measures

Name	Time	Method
Physical activity. Timepoint: beginning and end of intervention. Method of measurement: IPAQ questionnaire.;Energy intake. Timepoint: beginning and end of intervention. Method of measurement: Three-day food record.