The effect of hesperidin in myocardial infarctio
- Conditions
- Depression.Depressive episode
- Registration Number
- IRCT201702262394N36
- Lead Sponsor
- Vice chancellor for research, Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 70
willingness to cooperate and signed informed consent; Do not use any supplements during the last 3 months; including omega-3, 10 Q, antioxidants and vitamins; The absence of any allergies (gastrointestinal and skin) to any type of antioxidant supplements and vitamins, age 30 to 70 years; Beck Depression Inventory score more than 10; patients with MI from discharge to 6 weeks after MI; Do not use more than one blood orange or Do not use more than two other citrus fruits a day; BMI=25-40. Criteria of excluding: There are major psychiatric disorders in patients with history; treatment of depression over 1 year ago; taking more than 500 ml per day of flavonoid-rich beverages include tea, coffee, citrus juice; Major cognitive disorders or impaired cognitive function of the patient's history; Lack of follow-up after discharge; Smoking and tobacco; uncontrolled development of metabolic diseases; Pregnancy and lactation; Use heparin and warfarin. Exclusion criteria: The use of any antioxidant and vitamin supplements; View the latest allergy symptoms at any time during the study; unwillingness to continue the cooperation of the patient for any reason; uncontrolled chronic diseases ( Like: hepatic failure, renal failure, diabetes, etc.); digestive disorders; compliance below 80%; Earn each of the criteria of entry.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Depression. Timepoint: Before the intervention, after the intervention. Method of measurement: Beck standard questionnaire.
- Secondary Outcome Measures
Name Time Method Brain-Derived Neurotrophic Factor. Timepoint: Before the intervention, after the intervention. Method of measurement: ng per ml in the ELISA.;Cortisol. Timepoint: Before the intervention, after the intervention. Method of measurement: micrograms per deciliter, ELISA.