Comparison of AOCT and AOPT for the Treatment of Medial Large Cystic OLT

Completed

• Conditions: Osteochondral Lesions of the Talus
• Interventions: Procedure: AOCT; Procedure: AOPT

• Registration Number: NCT04950335
• Lead Sponsor: Peking University Third Hospital

Brief Summary

Autologous osteoperiosteal transplantation using tissue harvested from the iliac crest is used to treat large cystic osteochondral lesions of the talus. This study is to compare clinical and radiological outcomes between patients undergoing AOPT and those undergoing AOCT for large cystic OLTs.

Detailed Description

From March 2015 to March 2018, 23 patients who underwent AOPT and 23 patients who underwent AOCT to treat large cystic OLTs (\>10mm) were retrospectively evaluated. For comparability, the two groups were matched based on their demographics, including sex, age, body mass index, side of injury, follow-up period, and the preoperative cyst volume. Clinical outcomes were assessed using the visual analog scale (VAS), the American Orthopaedic Foot \& Ankle Society (AOFAS) score, and the Tegner score. Donor-site morbidity was recorded according to the symptoms, including pain, stiffness, swelling and discomfort. Radiological outcomes were evaluated using the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score, and the International Cartilage Repair Society (ICRS) score was obtained during second-look surgery.

Study Timeline

• Study Start: 2014-03-01
• Primary Completion: 2017-11-30
• Study Completion: 2020-11-10
• Status Verified: 2021-06
• Study First Submitted: 2021-06-25
• Study First Submitted QC: 2021-07-01
• Last Update Submitted: 2021-07-01
• Study First Posted: 2021-07-06
• Last Update Posted: 2021-07-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

• presence of medial large cystic OLTs (>10 mm in diameter) confirmed by preoperative magnetic resonance imaging (MRI)
• patients who underwent either primary AOPT or AOCT

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Exclusion Criteria

• small cystic OLTs
• ankle osteoarthritis
• ankle pigmented villonodular synovitis
• prior surgery on the ipsilateral ankle
• injuries or relevant trauma to the affected ankle after surgery

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
AOCT	AOCT	patients underwent AOCT to treat large cystic OLTs (\>10mm)
AOPT	AOPT	patients underwent AOPT to treat large cystic OLTs (\>10mm)

Primary Outcome Measures

Name	Time	Method
MOCART	two years after sugery	the Magnetic Resonance Observation of Cartilage Repair Tissue score

Secondary Outcome Measures

Name	Time	Method
VAS	pre-surgery, two years after sugery	the visual analog scale
ICRS	one year after sugery	the International Cartilage Repair Society score
Tegner	pre-surgery, two years after sugery	the Tegner score
AOFAS	pre-surgery, two years after sugery	American Orthopaedic Foot \& Ankle Society score