Radiation Biodosimetry in Children Undergoing Total Body Irradiation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- To describe changes in gene expression associated with exposure to radiation
研究概览
简要总结
The purpose of this study is to develop fecal tests that will determine the extent of radiation exposure in patients undergoing radiation treatment for cancer. This project will determine whether fecal biomarkers can be used to diagnose exposure to radiation.
详细描述
Patients undergoing TBI as part of a hematopoietic stem cell transplant (HSCT) will have feces collected for use in the validation and refinement of new methods for rapid radiation biodosimetry. The stool samples will be collected before, and at defined times after TBI. Stool sampling will occur in the same manner that it does during routine patient care during HSCT.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Years 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All races are eligible
- •2 years to 21 years old
- •Must be undergoing hematopoietic stem cell transplantation (either autologous or allogeneic) in conjunction with a conditioning regimen that includes total-body irradiation (TBI) (single or multiple fraction).
排除标准
- 未提供
结局指标
主要结局
To describe changes in gene expression associated with exposure to radiation
时间窗: prior to TBI treatment (baseline) and up to 2 weeks following the last dose of TBI
Changes in gene expression will be measured as abundance of RNA levels relative to the weight of feces
次要结局
未报告次要终点
研究者
John Baker
Professor of Surgery/Cardiothoracic/Research
Medical College of Wisconsin