NCT00749697Unknown不适用
Investigating Absorbed Radiation Dose Delivered to Differentiated Thyroid Cancer Metastases Following Administration of Fixed Activity of Radioactive Iodine
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- The primary outcome measure is to correlate the predicted dose from the tracer study with the actual absorbed dose measure on the therapeutic scan
研究概览
简要总结
The main purpose of the study is to establish a relationship between the administered activity of the radioiodine and absorbed dose in the tumor sites.
详细描述
Study Design - the assessment of patients with multiple tumour sites with metastatic thyroid cancer to correlate the administered activity to absorbed dose. Patients will receive the standard therapy dose of 5.5 GBq as per the hospital policy and there will be no change for the protocol purpose.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age above 18
- •histological confirmation of the differentiated thyroid carcinoma available
- •WHO performance score 0-2
- •metastatic sites lung and/or bone and/or nodal (radiologically measurable disease > 1 cm)
- •life expectancy > 6 months
- •patient has undergone total/near total thyroidectomy
- •no past history of sensitivity/reaction to 1311
排除标准
- •non iodine concentrating tumours
- •received chemotherapy or radiotherapy in 6 weeks
- •pregnant or breast feeding patients
- •iodine contrast injection in last 3 months
结局指标
主要结局
The primary outcome measure is to correlate the predicted dose from the tracer study with the actual absorbed dose measure on the therapeutic scan
次要结局
- The secondary outcomes will be to assess the response at 6 months post therapy in each patient
研究者
研究点 (2)
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