Study on Dose-effect Relationship Between Radiation Injury Dose and Expression of Associated microRNAs in Human Peripheral Blood
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Radiation Injuries, Experimental
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- expression levels of the microRNAs
- Last Updated
- 7 years ago
Overview
Brief Summary
Rapid and accurate assessment of radiation injury dose is the key to success in early treatment and an urgent issue to be solved in clinical medicine.Researches showed that the expression of the microRNAs in human peripheral blood had much correlation with radiation injury resulted from different dosages of radiation.In this study,acute leukemic patients who will be pretreated by whole-body radiation are taked as the object of study,and biochip technology are adopted to detect the expression levels of the microRNAs in subject peripheral blood before-and-after radiation,and different expression is tested and Bioinformatics prediction,to evaluate the correlation between radiation injury dose and expression levels of the microRNAs in human peripheral blood.
Investigators
Eligibility Criteria
Inclusion Criteria
- •subjects who suffer from acute leukemic subjects who accept chemotherapy within one month and will be pretreated by whole-body irradiation peripheral blood cells of subjects are approximate to those of healthy person aged between 18 and 50 years old subjects who are competent to give written informed consent subjects without other systemic diseases
Exclusion Criteria
- •subjects who suffer from serious other systemic diseases subjects who are unwilling or unable to cooperate with this clinical study other serious cases that probably hinder this clinical study
Outcomes
Primary Outcomes
expression levels of the microRNAs
Time Frame: 12 hours
the expression levels of the microRNAs in human peripheral blood before radiation，12 hours after radiation and 24 hours after radiation