Fetal brain imaging in fetuses at high risk of acquired anomalies
Completed
- Conditions
- acquired fetal brain damagehypoxic ischemic infectious encephalopathy100474381001033510026908
- Registration Number
- NL-OMON35261
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 400
Inclusion Criteria
zwangeren waarbij een infectie is aangetoond (toxoplasmose, cytomegalie), trauma hebben ondergaan of trombocytopenie (allo-immuun) of bij de foetus een groeirestrictie is aangetoond onder de 10de percentiel voor 30 weken zwangerschapsduur, hydrops (verdacht voor anemie, arythmie, parvo virus infectie of hydrothorax), monochriale tweeling, echoscopische hersenbevindingen passend bij verkregen afwijking.
Exclusion Criteria
age below 18 years
serious language or communication barrier
pacemaker (with respect to MRI)
familial chromosomal, syndromal or metabolic abnormality
confirmed chromosomal abnormality
suspected syndromal or metabolic abnormality
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>What is the added value of transvaginal ultrasound or MRI to abdominal<br /><br>ultrasound in a fetus at thig risk of deveoping brain damage in the second and<br /><br>third trimester of pregnancy.</p><br>
- Secondary Outcome Measures
Name Time Method <p>What is the prevalence of changes visible on antenatal ultrasound in the areas<br /><br>in the brain that are prone to hypoxic ischemic damage after birth.<br /><br>What is the evolution of these changes over time before and after birth.<br /><br>Which antenatal ultrasound findings are associated with abnormal neurological<br /><br>development until five years of age.<br /><br>At which gestational age can brain damage best be determined with<br /><br>transabdominal and transvaginal ultrasound and MRI.<br /><br>Which brain imaging procedures have the best predictive value for the<br /><br>neurological outcome at two and five uears of age and how are they related<br /><br>cost-effectively.</p><br>