Efficacy Testing of Hibiscus Sabdariffa Extract and Collagen Products

Not Applicable

Completed

• Conditions: Skin Condition
• Interventions: Dietary Supplement: Placebo sachet; Dietary Supplement: Hibiscus sabdariffa extract and collagen products

• Registration Number: NCT05988554
• Lead Sponsor: TCI Co., Ltd.

Brief Summary

To assess Hibiscus sabdariffa extract and collagen products on skin condition improvement

Detailed Description

Not available

Study Timeline

• Study Start: 2023-06-05
• Study First Submitted: 2023-08-04
• Study First Submitted QC: 2023-08-04
• Study First Posted: 2023-08-14
• Primary Completion: 2023-08-31
• Study Completion: 2023-12-31
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-19
• Last Update Posted: 2024-02-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Healthy adults aged above 20 years old

Exclusion Criteria

• Subject who is not willing to participate in this study.
• Patients with diseases of the skin, liver, kidney.
• Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
• Female who is pregnant or nursing or planning to become pregnant during the course of the study.
• Received facial laser therapy, chemical peeling or UV overexposure (> 3 hr/week) in the past 4 weeks.
• Constant drug use
• Students who are currently taking courses taught by the principal investigator of this trial.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo sachet	Placebo sachet	-
Hibiscus sabdariffa extract and collagen products	Hibiscus sabdariffa extract and collagen products	-

Primary Outcome Measures

Name	Time	Method
The change of skin wrinkles	Week 0, week 4, week 8	VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units
The change of skin elasticity	Week 0, week 4, week 8	SoftPlus was utilized to measure skin elasticity. Units: arbitrary units
The change of skin moisture	Week 0, week 4, week 8	Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120
The change of skin texture	Week 0, week 4, week 8	VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units
The change of skin collagen density	Week 0, week 4, week 8	DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units

Secondary Outcome Measures

Name	Time	Method
The change of skin L* value	Week 0, week 4, week 8	Chroma Meter MM500 was utilized to measure skin L\* value. Units: arbitrary units, 0-100
The change of skin spots	Week 0, week 4, week 8	VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units
The change of skin melanin index	Week 0, week 4, week 8	Mexameter® MX18 was utilized to measure skin melanin index. Units: arbitrary units
The change of transepidermal water loss (TEWL)	Week 0, week 4, week 8	Tewameter® TM 300 was utilized to measure TEWL. Units: g/hm²
The change of skin pores	Week 0, week 4, week 8	VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units

Trial Locations

Locations (1)

Chia Nan University of Pharmacy ＆ Science; 🇨🇳 Tainan, Taiwan