Comparison of the effect of Hibiscus sabdariffa L. extract and thiazide on albuminuria in patients with type 2 diabetes

Phase 3

Recruiting

Conditions: Type 2 diabetes.
Diabetes mellitus due to underlying condition with kidney complications
E08.2

Registration Number: IRCT20200522047538N1

Lead Sponsor: Gorgan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 105

Inclusion Criteria

40 to 70 years old2 Man or Non-pregnant woman
Provide conscious written and verbal consent
The patient should be admitted to the clinic with a diagnosis of type 2 diabetes confirmed
Blood pressure above 130/80 mm Hg
The person is willing and able to follow the study instructions and go to the clinic for a visit.

Exclusion Criteria

Allergic to the plant
Normal blood pressure (mm HgSBP = 120; DBP = 80 mm Hg)
Stage two and above
Patients with renal failure, coronary artery disease, heart failure .Pregnancy
Any metabolic or malabsorption disease that may interfere with the absorption of hibiscus (such as celiac disease, chronic pancreatitis, etc.).
Taking psychiatric medications (mood stabilizer, antidepressant, anti-anxiety or antipsychotic)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
rinary albumin. Timepoint: Albuminuria before the intervention and 3 months later. Method of measurement: Using a 24-hour urine collection test and examining the amount of protein and albumin excretion.

Secondary Outcome Measures

Name	Time	Method
Blood pressure. Timepoint: Blood pressure with a sphygmomanometer before the start of the intervention and three consecutive weeks after the start of the intervention and after the end of the intervention. Method of measurement: Blood pressure measurement is performed by an experienced and trained technician who is unaware of the intervention, in a blinded manner. According to the Kaplan protocol, the blood pressure of the patients after at least 5 minutes of rest in a sitting position for three consecutive weeks at a certain hour by It is measured by an experienced and trained technician. For this measurement, Richter's Nova model desktop mercury pressure gauge is used.