Examining the effect of electrical brain stimulation on food cue-induced craving by MRI

Not Applicable

Conditions: Food craving and obesity.
Overweight and obesity

Registration Number: IRCT20121020011172N4

Lead Sponsor: Cognitive Sciences & Technologies Council

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 65

Inclusion Criteria

1. Age =18 and <61 years old2. Persian speaking3. BMI: 25-354. Frequent food cravings (=3times/day during last month) in the screening self-report5. Positive response to food cue-reactivity screening (= 50% craving in visual analog scale)6. Willing and capable of interacting with the informed consent process

Exclusion Criteria

1. Unwillingness or inability to complete any of the major aspects of the study protocol, including magnetic resonance imaging (i.e., due to claustrophobia), food cue rating, or behavioral assessment.2. Comorbid severe psychiatric disorders (e.g. severe depression, bipolar, psychosis or background of suicide) Which is evaluated by a specialist.3. Active suicidal ideation with intent or plan determined by self-report or assessment by PI or study staff during the initial screening or any other phase of the study 4. Any active skin disorder that affects skin integrity of the scalp 5. Unstable medical disorder reported in subject’s medical history or by a clinician assessment6. Non-correctable vision or hearing problems7. History of brain injury or seizure 8. History of any brain stimulation 9. Any other condition the PI or study staff feel would put the subject at risk for entering the study

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood oxygen level dependent (BOLD) signal changes in the contrast between food and non-food images. Timepoint: Before and after of intervention. Method of measurement: BOLD signal differences with voxel-wise analysis in the regions of interests (ROIs) (Prefrontal cortex, Insula, Striatum, Thalamus and Extended Amygdala) in craving > neutral contrast in event-related design food cue exposure fMRI task.;Food Craving Self-Report. Timepoint: Before and after of intervention. Method of measurement: Subjective response to On a scale of 0-100, How much food craving are you experiencing RIGHT NOW measured on a visual analog scale (0-100).

Secondary Outcome Measures