Comparative study of the excretion of orange flavonoids, cv. Pera and cv. Moro juices, between lean and obese individuals
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
A large difference in the recovery of the urinary flavanone phase II metabolites was observed, with hesperetin-sulfate and hesperetin-sulfo-O-glucuronide being the major metabolites. Subjects were stratified according to their total excretion of flavanone metabolites as high, medium, and low excretors, but the expected correlation with the microbiome was not observed at the genus level. A second stratification was proposed according to phase II flavanone metabolism, whereby participants were divided into two excretion groups: Profiles A and B. Profile B individuals showed greater biotransformation of hesperetin-sulfate to hesperetin-sulfo-O-glucuronide, as well as transformation of flavanone-monoglucuronide to the respective diglucuronides, suggestive of an influence of polymorphisms on UDP-glucuronosyltransferase.
研究设计
- 研究类型
- Intervention
入排标准
- 年龄范围
- 19Y 至 40Y（—）
- 性别
- Female
入选标准
- •No history of gastrointestinal, hepatic or renal disease;Do not be an alcoholic;Do not be diabetic;Do not be a vegetarian;Do not present any type of infection;Not be making use of vitamin and mineral supplements;Do not be a smoker;Do not practice intense physical activity;They can not be pregnant, breastfeeding or reporting hormone therapy for menopause
排除标准
- •Be under 19 and over 40 years old;Do not be female;Have intestinal, kidney or liver disease;Being a vegetarian or a smoker;Practice intense physical activity;Being pregnant or breastfeeding