Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)
- Registration Number
- NCT04888585
- Lead Sponsor
- AbbVie
- Brief Summary
Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. This study evaluated how safe and effective ABBV-154 is in participants treated for moderately to severely active RA. Adverse events and change in the disease activity were assessed.
ABBV-154 is an investigational drug being evaluated for the treatment of RA. Study doctors placed the participants in 1 of 5 treatment groups or arms; each arm received a different treatment. There was a 1 in 5 chance that participants were assigned to placebo. Participants 18-75 years of age with moderate to severe RA were enrolled. Around 425 participants were to be enrolled in the study at approximately 270 sites worldwide.
The study was comprised of a 12 week placebo-controlled period, a double-blind long term extension (LTE) period 1 of 66 weeks, a LTE period 2 of 104 weeks and a follow-up visit 70 days after the last dose of the study drug. In the LTE period 1, participants in the placebo group were re-randomized to receive ABBV-154 at 1 of 2 different doses SC every other week (EOW). Other participants remained on their previous dose and dosing regimen of ABBV-154.
There may have been a higher treatment burden for participants in this trial compared to their standard of care. Participants attended regular visits during the study at a hospital or clinic. The effect of the treatment was checked by medical assessments, blood tests, and side effects, and completing questionnaires.
- Detailed Description
Participants were randomly assigned at a ratio of 1:1:1:1:1 to ABBV-154 at either 40 mg, 150 mg, 340 mg, subcutaneously (SC) EOW; 340 mg SC every 4 weeks (E4W); or placebo SC EOW. Randomization was stratified by baseline glucocorticoid (yes/no); number of prior failed biologic and/or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) (1; 2 or more); and prior anti-TNF failure (yes/no) and if yes, further stratification by prior adalimumab use (yes/no).
After 12 weeks, participants receiving placebo were re-randomized to receive ABBV-154 150 mg SC EOW or 340 mg SC EOW for the long-term extension (LTE) periods. At re-randomization, participants were stratified by baseline glucocorticoid use (yes/no) and prior adalimumab use (yes/no). Participants from the other dose groups were to continue with their respective dose and dosing regimen.
The primary analysis was conducted after all ongoing participants completed Week 12 or withdrew from the study. A final analysis was to be conducted after all participants completed LTE period 2 and a safety follow-up visit or withdrew from the study. The study was terminated before any participants entered LTE Period 2.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 473
- Clinical diagnosis of rheumatoid arthritis(RA) with fulfillment of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for RA.
- Participant has >= 6 swollen joints (based on 66 joint count) and >=6 tender joints (based on 68 joint count) at baseline.
- Participant must have had an inadequate response to at least one prior biologic and/or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) treatment for RA.
- Participants must be on stable dose of methotrexate (MTX).
- Participant discontinued prior adalimumab therapy due to intolerability or toxicity.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Participants in this group will receive placebo SC eow for 12 weeks in the placebo-controlled period and will be re-randomized in 1:1 ratio to receive ABBV-154 dose B or C respectively SC eow for 66 weeks in the LTE period 1 and 104 weeks in LTE period 2. Dose A of ABBV-154 ABBV-154 Participants in this group will receive dose A of ABBV-154 subcutaneously (SC) every other week (eow) for 12 weeks in the placebo-controlled period, 66 weeks in the long term extension (LTE) period 1 and 104 weeks in LTE period 2. Dose B of ABBV-154 ABBV-154 Participants in this group will receive dose B of ABBV-154 SC eow for 12 weeks in the placebo-controlled period, 66 weeks in the LTE period 1 and 104 weeks in LTE period 2. Dose C of ABBV-154 EOW ABBV-154 Participants in this group will receive dose C of ABBV-154 SC eow for 12 weeks in the placebo-controlled period, 66 weeks in the LTE period 1 and 104 weeks in LTE period 2. Dose C of ABBV-154 E4W ABBV-154 Participants in this group will receive dose C of ABBV-154 SC every 4 weeks (e4w) for 12 weeks in the placebo-controlled period, 66 weeks in the LTE period 1 and 104 weeks in LTE period 2. Placebo ABBV-154 Participants in this group will receive placebo SC eow for 12 weeks in the placebo-controlled period and will be re-randomized in 1:1 ratio to receive ABBV-154 dose B or C respectively SC eow for 66 weeks in the LTE period 1 and 104 weeks in LTE period 2.
- Primary Outcome Measures
Name Time Method Achievement of 50% Improvement as Measured by American College of Rheumatology Response Criteria (ACR50) at Week 12 Week 12 Participants who met the following 3 conditions for improvement from baseline were classified as meeting the ACR50 response criteria:
1. ≥ 50% improvement in 68-tender joint count;
2. ≥ 50% improvement in 66-swollen joint count; and
3. ≥ 50% improvement in at least 3 of the 5 following parameters:
* Physician's Global Assessment of Disease Activity (NRS)
* Patient's Global Assessment of Disease Activity (NRS)
* Patient's Assessment of Pain (NRS)
* Health Assessment Questionnaire - Disability Index (HAQ-DI)
* High-sensitivity C-reactive protein (hsCRP).
- Secondary Outcome Measures
Name Time Method Change From Baseline in Disease Activity Score (DAS) 28 (CRP) at Week 12 Baseline to Week 12 The DAS28 is a composite index used to assess rheumatoid arthritis disease activity, calculated based on the tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS), and hsCRP (in mg/L). Scores on the DAS28 range from 0 to approximately 10, where higher scores indicate more disease activity. A negative change from Baseline in DAS28 (CRP) indicates improvement in disease activity.
Change in Clinical Disease Activity Index (CDAI) at Week 12 Baseline to Week 12 CDAI is a composite index for assessing disease activity based on the sum of the total tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS), and Physician's Global Assessment of Disease Activity (NRS). The total CDAI score ranges from 0 to 76 with higher scores indicating higher disease activity.
Percentage of Participants Achieving American College of Rheumatology 20% (ACR20) Response at Week 12 Week 12 Participants who met the following 3 conditions for improvement from baseline were classified as meeting the ACR20 response criteria:
1. ≥ 20% improvement in 68-tender joint count;
2. ≥ 20% improvement in 66-swollen joint count; and
3. ≥ 20% improvement in at least 3 of the 5 following parameters:
* Physician's Global Assessment of Disease Activity (NRS)
* Patient's Global Assessment of Disease Activity (NRS)
* Patient's Assessment of Pain (NRS)
* Health Assessment Questionnaire - Disability Index (HAQ-DI)
* High-sensitivity C-reactive protein (hsCRP).Percentage of Participants Achieving American College of Rheumatology 70% (ACR70) Response at Week 12 Week 12 Participants who met the following 3 conditions for improvement from baseline were classified as meeting the ACR70 response criteria:
1. ≥ 70% improvement in 68-tender joint count;
2. ≥ 70% improvement in 66-swollen joint count; and
3. ≥ 70% improvement in at least 3 of the 5 following parameters:
* Physician's Global Assessment of Disease Activity (NRS)
* Patient's Global Assessment of Disease Activity (NRS)
* Patient's Assessment of Pain (NRS)
* Health Assessment Questionnaire - Disability Index (HAQ-DI)
* High-sensitivity C-reactive protein (hsCRP).Percentage of Participants Achieving Low Disease Activity (LDA) Defined by DAS28 (CRP) <= 3.2 at Week 12 Week 12 Low disease activity (LDA) was defined as a DAS28 score less than or equal to 3.2. The DAS28 is a composite index used to assess rheumatoid arthritis disease activity, calculated based on the tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS) and Physician's Global Assessment of Disease Activity (NRS), and hsCRP (in mg/L). Scores on the DAS28 range from 0 to approximately 10, where higher scores indicate more disease activity.
Percentage of Participants Achieving LDA Defined by CDAI <= 10 at Week 12 Week 12 Low disease activity based on CDAI is defined as a CDAI score less than or equal to 10. CDAI is a composite index for assessing disease activity based on the sum of the total tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS), and Physician's Global Assessment of Disease Activity (NRS). The total CDAI score ranges from 0 to 76 with higher scores indicating higher disease activity.
Percentage of Participants Achieving Clinical Remission (CR) Defined by DAS28 (CRP) < 2.6 at Week 12 Week 12 Clinical remission was defined as a DAS28 (CRP) score less than 2.6. The DAS28 is a composite index used to assess rheumatoid arthritis disease activity, calculated based on the tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS), and hsCRP (in mg/L). Scores on the DAS28 range from 0 to approximately 10, where higher scores indicate more disease activity.
Percentage of Participants Achieving CR Defined by CDAI <= 2.8 at Week 12 Week 12 Clinical Remission was defined by CDAI as a score less than or equal to 2.8. CDAI is a composite index for assessing disease activity based on the summation of the total tender joint count (out of 28 evaluated joints), swollen joint count (out of 28 evaluated joints), Patient's Global Assessment of Disease Activity (NRS), and Physician's Global Assessment of Disease Activity (NRS). The total CDAI score ranges from 0 to 76 with higher scores indicating higher disease activity.
Change From Baseline in the Health Assessment Questionnaire Disability Index (HAQ-DI) to Week 12 Baseline to Week 12 The Health Assessment Questionnaire - Disability Index is a participant-reported questionnaire that measures the degree of difficulty a person has in accomplishing tasks in 8 functional areas (dressing, arising, eating, walking, hygiene, reaching, gripping, and errands and chores) over the past week. Participants assessed their ability to do each task on a scale from 0 (without any difficulty) to 3 (unable to do). Scores were averaged to provide an overall score ranging from 0 to 3, where 0 represents no disability and 3 represents very severe, high-dependency disability. A negative change from Baseline in the overall score indicates improvement.
Trial Locations
- Locations (220)
Purushotham & Akther Kotha MD, Inc /ID# 228120
🇺🇸La Mesa, California, United States
International Medical Research /ID# 228069
🇺🇸Daytona Beach, Florida, United States
Neoclinical Research /ID# 228753
🇺🇸Hialeah, Florida, United States
Omega Research Group /ID# 229966
🇺🇸Orlando, Florida, United States
Dr Naik-Medical Professional Corporation-Alliance Health /ID# 227823
🇨🇦Saskatoon, Saskatchewan, Canada
Aotearoa Clinical Trials /ID# 229012
🇳🇿Papatoetoe, Auckland, New Zealand
ClinicMed Daniluk, Nowak Sp.k. /ID# 227919
🇵🇱Bialystok, Podlaskie, Poland
MICS Centrum Medyczne Warszawa /ID# 231133
🇵🇱Warsaw, Poland
Hospital Regional Universitario de Malaga /ID# 227418
🇪🇸Malaga, Spain
MNI City Multidisciplinary Hospital #18 Kharkiv City Council /ID# 228961
🇺🇦Kharkiv, Ukraine
Medical Center "OK! Clinic+" LLC, "International Institute of Clinical Research" /ID# 228958
🇺🇦Kyiv, Ukraine
PI "Poltava Regional Clinical Hospital n.a. M.V.Sklifosovsky of PCC" /ID# 228962
🇺🇦Poltava, Ukraine
Сlinic Scientific Research Inst of Invalid Rehab ESMС M I Pyrogov VNMU /ID# 228955
🇺🇦Vinnytsia, Ukraine
Elite Clinical Studies, LLC /ID# 228227
🇺🇸Phoenix, Arizona, United States
Arthritis and Rheumatism Associates /ID# 228201
🇺🇸Jonesboro, Arkansas, United States
Providence Medical Foundation /ID# 228104
🇺🇸Fullerton, California, United States
Care Access Research, Huntington Beach /ID# 228163
🇺🇸Huntington Beach, California, United States
Arthritis & Osteo Medical Ctr /ID# 228239
🇺🇸La Palma, California, United States
Pacific Arthritis Care Center - Los Angeles /ID# 229330
🇺🇸Los Angeles, California, United States
California Medical Research Associates /ID# 230131
🇺🇸Northridge, California, United States
Arthritis Care And Research Center ACRC /ID# 230099
🇺🇸Poway, California, United States
East Bay Rheumatology Medical /ID# 228099
🇺🇸San Leandro, California, United States
Millennium Clinical Trials /ID# 230618
🇺🇸Thousand Oaks, California, United States
The Lundquist Institute at Harbor-UCLA Medical Center /ID# 228241
🇺🇸Torrance, California, United States
Medvin Clinical Research /ID# 228181
🇺🇸Tujunga, California, United States
Inland Rheum & Osteo Med Grp /ID# 228204
🇺🇸Upland, California, United States
Comprehensive Rheumatology Center /ID# 230132
🇺🇸Woodland Hills, California, United States
Denver Arthritis Clinic /ID# 228172
🇺🇸Denver, Colorado, United States
New England Research Associates, LLC /ID# 230127
🇺🇸Bridgeport, Connecticut, United States
Stamford Therapeutics Consorti /ID# 229214
🇺🇸Stamford, Connecticut, United States
Delaware Arthritis /ID# 229413
🇺🇸Lewes, Delaware, United States
Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 228229
🇺🇸Boca Raton, Florida, United States
Bay Area Arthritis and Osteo /ID# 228075
🇺🇸Brandon, Florida, United States
Clinical Research of West Florida, Inc /ID# 228128
🇺🇸Clearwater, Florida, United States
Omega Research Debary, LLC /ID# 228293
🇺🇸DeBary, Florida, United States
University of Florida /ID# 228242
🇺🇸Jacksonville, Florida, United States
Lakes Research, LLC /ID# 228665
🇺🇸Miami, Florida, United States
University of Miami /ID# 228737
🇺🇸Miami, Florida, United States
Suncoast Clinical Research /ID# 228237
🇺🇸New Port Richey, Florida, United States
HMD Research LLC /ID# 228185
🇺🇸Orlando, Florida, United States
Millennium Research /ID# 228183
🇺🇸Ormond Beach, Florida, United States
Arthritis Center, Inc. /ID# 228209
🇺🇸Palm Harbor, Florida, United States
BayCare Medical Group /ID# 228289
🇺🇸Saint Petersburg, Florida, United States
West Broward Rheumatology Associates /ID# 228603
🇺🇸Tamarac, Florida, United States
Clinical Research of West Florida - Tampa /ID# 228186
🇺🇸Tampa, Florida, United States
Conquest Research /ID# 230560
🇺🇸Winter Park, Florida, United States
Florida Medical Clinic /ID# 228236
🇺🇸Zephyrhills, Florida, United States
Arthritis and Rheumatology /ID# 228743
🇺🇸Atlanta, Georgia, United States
Jefrey D. Lieberman, MD, P.C. /ID# 230129
🇺🇸Decatur, Georgia, United States
Arthritis Center of North GA /ID# 228769
🇺🇸Gainesville, Georgia, United States
Atlanta Research Center for Rheumatology /ID# 230430
🇺🇸Marietta, Georgia, United States
Great Lakes Clinical Trials /ID# 228699
🇺🇸Chicago, Illinois, United States
Greater Chicago Specialty Physicians /ID# 228282
🇺🇸Schaumburg, Illinois, United States
Clinic of Robert Hozman/Clinical Investigation Specialists /ID# 228174
🇺🇸Skokie, Illinois, United States
Springfield Clinic /ID# 228124
🇺🇸Springfield, Illinois, United States
Beacon Medical Group Clinical Research /ID# 229153
🇺🇸Granger, Indiana, United States
University of Iowa Hospitals and Clinics /ID# 229217
🇺🇸Iowa City, Iowa, United States
Four Rivers Clinical Research /ID# 230109
🇺🇸Paducah, Kentucky, United States
The Arthritis & Diabetes Clinic, Inc. /ID# 228221
🇺🇸Monroe, Louisiana, United States
Klein and Associates MD /ID# 230145
🇺🇸Cumberland, Maryland, United States
Klein and Associates MD - Hagerstown /ID# 230143
🇺🇸Hagerstown, Maryland, United States
The Center for Rheumatology and Bone Research /ID# 228617
🇺🇸Wheaton, Maryland, United States
AA Medical Research Center - Grand Blanc /ID# 228604
🇺🇸Grand Blanc, Michigan, United States
Advanced Rheumatology, PC /ID# 228684
🇺🇸Lansing, Michigan, United States
June DO, PC /ID# 229838
🇺🇸Lansing, Michigan, United States
Arthritis Associates /ID# 230188
🇺🇸Hattiesburg, Mississippi, United States
Rheumatology Consultants - Clinical Research /ID# 229208
🇺🇸Tupelo, Mississippi, United States
Clayton Medical Associates, P.C. dba Saint Louis Rheumatology /ID# 228283
🇺🇸Saint Louis, Missouri, United States
West County Rheumatology /ID# 228102
🇺🇸Saint Louis, Missouri, United States
Logan Health Research /ID# 228273
🇺🇸Kalispell, Montana, United States
Advanced Biomedical Research of America /ID# 228596
🇺🇸Las Vegas, Nevada, United States
Innovative Health Research /ID# 229209
🇺🇸Las Vegas, Nevada, United States
Arthritis and Osteoporosis Associates /ID# 229418
🇺🇸Freehold, New Jersey, United States
Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 228602
🇺🇸Voorhees, New Jersey, United States
Albuquerque Center For Rheumatology /ID# 228709
🇺🇸Albuquerque, New Mexico, United States
Albuquerque Clinical Trials, Inc /ID# 228925
🇺🇸Albuquerque, New Mexico, United States
Arthritis and Osteo Assoc /ID# 228662
🇺🇸Las Cruces, New Mexico, United States
Buffalo Rheumatology and Medicine - Orchard Park /ID# 228710
🇺🇸Orchard Park, New York, United States
St. Lawrence Health System /ID# 229508
🇺🇸Potsdam, New York, United States
DJL Clinical Research, PLLC /ID# 230133
🇺🇸Charlotte, North Carolina, United States
Cape Fear Arthritis Care /ID# 228747
🇺🇸Leland, North Carolina, United States
PMG Research of Salisbury /ID# 230627
🇺🇸Salisbury, North Carolina, United States
Trinity Health Med Arts Clinic /ID# 228202
🇺🇸Minot, North Dakota, United States
University of Cincinnati /ID# 229212
🇺🇸Cincinnati, Ohio, United States
Paramount Medical Research Con /ID# 228254
🇺🇸Middleburg Heights, Ohio, United States
Arthritis Assoc of NW Ohio /ID# 228936
🇺🇸Toledo, Ohio, United States
Arthritis and Rheumatology Center of Oklahoma /ID# 228975
🇺🇸Oklahoma City, Oklahoma, United States
Rheumatology Associates of Oklahoma /ID# 228701
🇺🇸Oklahoma City, Oklahoma, United States
Advanced Rheumatology & Arthritis Wellness Center /ID# 228608
🇺🇸Cranberry Township, Pennsylvania, United States
Altoona Ctr Clinical Res /ID# 230058
🇺🇸Duncansville, Pennsylvania, United States
Arthritis Group /ID# 229777
🇺🇸Philadelphia, Pennsylvania, United States
PA Regional Center for Arthritis and Osteoporosis Research /ID# 228742
🇺🇸Wyomissing, Pennsylvania, United States
Columbia Arthritis Center /ID# 228705
🇺🇸Columbia, South Carolina, United States
West Tennessee Research Institute /ID# 228257
🇺🇸Jackson, Tennessee, United States
Arthritis and Rheumatology Research Institute, PLLC /ID# 228937
🇺🇸Allen, Texas, United States
Allen Arthritis /ID# 228712
🇺🇸Allen, Texas, United States
Trinity Universal Research Associates - Carrollton /ID# 230104
🇺🇸Carrollton, Texas, United States
Adriana Pop-Moody MD Clinic PA /ID# 230062
🇺🇸Corpus Christi, Texas, United States
West Texas Clinical Research /ID# 228276
🇺🇸Lubbock, Texas, United States
P&I Clinical Research /ID# 230183
🇺🇸Lufkin, Texas, United States
SW Rheumatology Res. LLC /ID# 228088
🇺🇸Mesquite, Texas, United States
Trinity Universal Research Associates, Inc /ID# 228238
🇺🇸Plano, Texas, United States
Epic Medical Research /ID# 228097
🇺🇸Red Oak, Texas, United States
Sun Research Institute /ID# 228768
🇺🇸San Antonio, Texas, United States
Advanced Rheumatology of Houston /ID# 228170
🇺🇸The Woodlands, Texas, United States
DM Clinical Research - Tomball /ID# 228112
🇺🇸Tomball, Texas, United States
Rheumatology Clinic of Houston /ID# 228178
🇺🇸Tomball, Texas, United States
Arthritis & Osteoporosis Clinic /ID# 228736
🇺🇸Waco, Texas, United States
Tidewater Physicians Medical Center /ID# 230130
🇺🇸Newport News, Virginia, United States
Arthritis Northwest, PLLC /ID# 228275
🇺🇸Spokane, Washington, United States
Emeritus Research Sydney /ID# 230070
🇦🇺Botany, New South Wales, Australia
BJC Health /ID# 229015
🇦🇺Paramatta, New South Wales, Australia
Rheumatology Research Unit Sunshine Coast /ID# 229017
🇦🇺Maroochydore, Queensland, Australia
The Queen Elizabeth Hospital /ID# 230071
🇦🇺Woodville South, South Australia, Australia
Emeritus Research /ID# 229018
🇦🇺Camberwell, Victoria, Australia
Rheumatology Research Associates /ID# 227818
🇨🇦Edmonton, Alberta, Canada
Manitoba Clinic /ID# 227822
🇨🇦Winnipeg, Manitoba, Canada
Groupe de Recherche en Maladies Osseuses Inc /ID# 227821
🇨🇦Sainte-foy, Quebec, Canada
Centre de Recherche Musculo-Squelettique /ID# 227824
🇨🇦Trois-rivières, Quebec, Canada
Revmatologicky ustav v Praze /ID# 229188
🇨🇿Praha, Czechia
PV MEDICAL Services s.r.o. /ID# 228265
🇨🇿Praha, Czechia
Revmatologicka ambulance - MUDr. Zuzana Urbanova /ID# 227775
🇨🇿Praha, Czechia
Fakultni Nemocnice v Motole /ID# 231622
🇨🇿Praha, Czechia
MEDICAL PLUS, s.r.o. /ID# 228030
🇨🇿Uherske Hradiste, Czechia
RHEUMA s.r.o. /ID# 230850
🇨🇿Velke Bilovice, Czechia
Rheumazentrum Ruhrgebiet /ID# 227850
🇩🇪Herne, Nordrhein-Westfalen, Germany
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 229526
🇩🇪Berlin, Germany
MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH /ID# 227785
🇩🇪Hamburg, Germany
General Hospital of Athens Gennimatas /ID# 227806
🇬🇷Athens, Attiki, Greece
University General Hospital of Heraklion PA.G.N.I /ID# 227804
🇬🇷Heraklion, Kriti, Greece
424 General MILITARY Hospital /ID# 227805
🇬🇷Efkarpia (Thessalonikis), Thessaloniki, Greece
General Hospital of Thessaloniki Hippokrateio /ID# 229614
🇬🇷Thessaloniki, Greece
Debreceni Egyetem Klinikai Kozpont /ID# 228371
🇭🇺Debrecen, Hajdu-Bihar, Hungary
Obudai Egeszsegugyi Centrum Kft. /ID# 228359
🇭🇺Budapest, Pest, Hungary
DRC Gyogyszervizsgalo Kozpont Kft /ID# 228365
🇭🇺Balatonfüred, Hungary
Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 227671
🇭🇺Budapest, Hungary
Revita Reumatologiai Rendelo /ID# 227668
🇭🇺Budapest, Hungary
CMED Rehabilitacios es Diagnosztikai Kozpont /ID# 227670
🇭🇺Szekesfehervar, Hungary
Vital Medical Center Orvosi es Fogaszati Kozpont (Vital Medicina Kft.) /ID# 227669
🇭🇺Veszprém, Hungary
Obudai Egeszsegugyi Centrum Kft. Zalaegerszeg /ID# 228374
🇭🇺Zalaegerszeg, Hungary
Rambam Health Care Campus /ID# 226798
🇮🇱Haifa, H_efa, Israel
Bnai Zion Medical Center /ID# 226801
🇮🇱Haifa, H_efa, Israel
The Lady Davis Carmel Medical Center /ID# 226802
🇮🇱Haifa, H_efa, Israel
Meir Medical Center /ID# 226800
🇮🇱Kfar Saba, HaMerkaz, Israel
The Chaim Sheba Medical Center /ID# 226797
🇮🇱Ramat Gan, Tel-Aviv, Israel
Tel Aviv Sourasky Medical Center /ID# 228341
🇮🇱Tel Aviv, Tel-Aviv, Israel
Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 228917
🇮🇹Rome, Lazio, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona /ID# 228581
🇮🇹Ancona, Italy
Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 228583
🇮🇹Palermo, Italy
Japan Organization of Occupational Health and Safety Chubu Rosai Hospital /ID# 229899
🇯🇵Nagoya-shi, Aichi, Japan
Daido Clinic /ID# 229280
🇯🇵Nagoya-shi, Aichi, Japan
Sugimoto rheumatology and internal medicine clinic /ID# 229495
🇯🇵Fukui-shi, Fukui, Japan
National Hospital Organization Kyushu Medical Center /ID# 228642
🇯🇵Fukuoka shi, Fukuoka, Japan
Hamanomachi Hospital /ID# 228644
🇯🇵Fukuoka-shi, Fukuoka, Japan
Shono Rheumatism Clinic /ID# 229054
🇯🇵Fukuoka-shi, Fukuoka, Japan
Katayama Orthopedic Rheumatology Clinic /ID# 229277
🇯🇵Asahikawa-shi, Hokkaido, Japan
Sagawa Akira Rheumatology Clin /ID# 228787
🇯🇵Sapporo-shi, Hokkaido, Japan
Matsubara Mayflower Hospital /ID# 228948
🇯🇵Kato-shi, Hyogo, Japan
Sanuki Municipal Hospital /ID# 229276
🇯🇵Sanuki-shi, Kagawa, Japan
Bay Side Misato Medical Center /ID# 228947
🇯🇵Kochi-shi, Kochi, Japan
Kumamoto Orthopaedic Hospital /ID# 228641
🇯🇵Kumamoto shi, Kumamoto, Japan
Medical Corporation Keiai Kai Clinic /ID# 228547
🇯🇵Miyazaki-shi, Miyazaki, Japan
Sasebo Chuo Hospital /ID# 229168
🇯🇵Sasebo-shi, Nagasaki, Japan
Nagaoka Red Cross Hospital /ID# 229962
🇯🇵Nagaoka-shi, Niigata, Japan
National Hospital Organization Osaka Minami Medical Center /ID# 229174
🇯🇵Kawachinagano Shi, Osaka, Japan
Osaka City General Hospital /ID# 228786
🇯🇵Osaka-shi, Osaka, Japan
Japanese Red Cross Osaka Hospital /ID# 229816
🇯🇵Osaka-shi, Osaka, Japan
Azuma Rheumatology Clinic /ID# 230078
🇯🇵Sayama-shi, Saitama, Japan
St.Luke's International Hospital /ID# 229492
🇯🇵Chuo-ku, Tokyo, Japan
National Hospital Organization Tokyo Medical Center /ID# 228720
🇯🇵Meguro-ku, Tokyo, Japan
Medical Corporation Uchida Clinic /ID# 229494
🇯🇵Sumida-ku, Tokyo, Japan
Tokito Clinic Rheumatology and Orthopaedics Surgery /ID# 228354
🇯🇵Shimonoseki-shi, Yamaguchi, Japan
SoonChunHyang University CheonAn Hospital /ID# 228146
🇰🇷Cheonan-si, Chungcheongnamdo, Korea, Republic of
Yonsei University Health System Severance Hospital /ID# 227659
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Hanyang University Seoul Hospital /ID# 227658
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Kyungpook National University Hospital /ID# 227657
🇰🇷Daegu, Korea, Republic of
Inha University Hospital /ID# 227656
🇰🇷Incheon, Korea, Republic of
Asan Medical Center /ID# 227655
🇰🇷Seoul, Korea, Republic of
Academisch Medisch Centrum /ID# 227234
🇳🇱Amsterdam, Netherlands
Maastricht Universitair Medisch Centrum /ID# 227235
🇳🇱Maastricht, Netherlands
Timaru Medical Specialists Ltd /ID# 229013
🇳🇿Timaru, Canterbury, New Zealand
Wellington Regional Hospital /ID# 233517
🇳🇿Newtown, Wellington, New Zealand
Szpital Uniwersytecki nr 2 im. dr. Jana Biziela /ID# 227939
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
AMICARE Sp. z o.o. sp.k. /ID# 231327
🇵🇱Lodz, Lodzkie, Poland
Centrum Medyczne Reuma Park /ID# 227170
🇵🇱Warszawa, Mazowieckie, Poland
SANUS Szpital Specjalistyczny /ID# 227171
🇵🇱Stalowa Wola, Podkarpackie, Poland
Centrum Badan Klinicznych PI-House sp. z o.o. /ID# 228047
🇵🇱Gdansk, Pomorskie, Poland
GCM Medical Group PSC /ID# 228981
🇵🇷San Juan, Puerto Rico
Mindful Medical Research /ID# 228982
🇵🇷San Juan, Puerto Rico
Moscow Regional Research and Clinical Institute n.a. Vladimirskiy (MONIKI) /ID# 228755
🇷🇺Moscow, Moskovskaya Oblast, Russian Federation
LLC Family Outpatient Clinic No /ID# 227926
🇷🇺Korolev, Moskva, Russian Federation
Family Clinic /ID# 227929
🇷🇺Yekaterinburg, Sverdlovskaya Oblast, Russian Federation
Kazan State Medical University /ID# 227927
🇷🇺Kazan, Tatarstan, Respublika, Russian Federation
Central Clinical Hospital of Russian Academy of Science /ID# 229438
🇷🇺Moscow, Russian Federation
Euromedservice /ID# 227933
🇷🇺Pushkin, Russian Federation
Clinical Rheumatologic Hospital No 25 /ID# 227922
🇷🇺St. Petersburg, Russian Federation
MEDMAN s.r.o. /ID# 227826
🇸🇰Martin, Slovakia
Reum.hapi s.r.o. /ID# 227825
🇸🇰Nove Mesto nad Vahom, Slovakia
Thermium s.r.o. /ID# 227816
🇸🇰Piestany, Slovakia
REUMAMED POPRAD s.r.o. /ID# 229628
🇸🇰Poprad, Slovakia
Reumex, s.r.o. /ID# 227827
🇸🇰Rimavska Sobota, Slovakia
Hospital Clínico Universitario de Santiago-CHUS /ID# 227420
🇪🇸Santiago de Compostela, A Coruna, Spain
Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 227666
🇪🇸Sabadell, Barcelona, Spain
Hospital Universitario Basurto /ID# 227667
🇪🇸Bilbao, Vizcaya, Spain
Hospital Universitario A Coruna - CHUAC /ID# 227419
🇪🇸A Coruna, Spain
Hospital Universitario Fundacion Jimenez Diaz /ID# 234115
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre /ID# 227743
🇪🇸Madrid, Spain
Hospital Universitario Virgen de Valme /ID# 227417
🇪🇸Sevilla, Spain
Hospital Universitario y Politecnico La Fe /ID# 227408
🇪🇸Valencia, Spain
Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation /ID# 227220
🇨🇳Chia-Yi, Taiwan
Far Eastern Memorial Hospital /ID# 227373
🇨🇳New Taipei City, Taiwan
National Taiwan University Hospital /ID# 230001
🇨🇳Taipei City, Taiwan
Taipei Veterans General Hosp /ID# 227376
🇨🇳Taipei, Taiwan
Hacettepe Universitesi Tip Fak /ID# 227796
🇹🇷Sihhiye, Ankara, Turkey
Ankara Univ Medical Faculty /ID# 227797
🇹🇷Ankara, Turkey
Kocaeli University Med Faculty /ID# 228244
🇹🇷Kocaeli, Turkey
Khmelnytskyi Regional Hospital /ID# 230680
🇺🇦Khmelnytskyi, Ukraine
Medical Center of Medical Clinic Blagomed LLC /ID# 228956
🇺🇦Kyiv, Ukraine
Medical Center CONSILIUM MEDICAL /ID# 228959
🇺🇦Kyiv, Ukraine
CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 228954
🇺🇦Vinnytsia, Ukraine