Quantitative EEG Markers in Mild Cognitive Impairment in Epilepsy

Completed

• Conditions: Epilepsy
• Interventions: Device: Electroencephalography

• Registration Number: NCT04376671
• Lead Sponsor: Mansoura University Hospital

Brief Summary

Epileptic patients are plighted with limited daily activities, social dysfunction, family conflicts and cognitive impairment. Most of the studies had showed that cognitive disorders were frequent in patients with epilepsy.The cognitive impairment has been reported in around 25% of epileptic patients.

Detailed Description

Cognitive consequences in epilepsy are often described in the following domains: verbal memory, language, executive functions, and attention. However, most of the studies focus on one or two domains in a relatively small sample.

Few studies have investigated the influential factors for the epilepsy-related cognitive impairment . However, most of these studies merely focused on one or a few potential factors and failed to consider possible distractions from other influential factors. Therefore, it is crucial to include more potential factors in the analysis and to rule out possible confounding interactions between factors.

Study Timeline

• Study Start: 2019-03-01
• Primary Completion: 2020-02-01
• Study Completion: 2020-03-01
• Status Verified: 2020-05
• Study First Submitted: 2020-05-03
• Study First Submitted QC: 2020-05-03
• Last Update Submitted: 2020-05-03
• Study First Posted: 2020-05-06
• Last Update Posted: 2020-05-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Patients with clinically confirmed epilepsy in adult patients.
• Non-symptomatic epilepsy.
• Normal CT or MRI brain, and
• Education level of primary school at least to respond to the scales correctly were included.

Exclusion Criteria

• Psycho-neurological illnesses,
• History of alcoholism or drug abuse, or
• Recently on medications that may affect cognitive functions (like antidepressants and antipsychotic drugs).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Extra-temporal lobe epilepsy	Electroencephalography	Group of patients with extra-temporal lobe epilepsy
temporal lobe epilepsy	Electroencephalography	Group of patients with temporal lobe epilepsy

Primary Outcome Measures

Name	Time	Method
Mini-mental state examination (MMSE)	24 hours	This is a rapid screening tool to estimate the cognitive functions that evaluates orientation, basic attention, working memory, learning, naming, construction, comprehension, and repetition. The maximum score is 30 and scores below 24 indicating cognitive impairment.
Montreal cognitive assessment (MoCA)	24 hours	Montreal cognitive assessment is a rapid sensitive screening tool for assessment of impaired cognitive function (Nasreddine et al., 2005). The main domains of MoCA scale include attention, executive functions, memory, language, attention, naming, orientation, and visual-spatial ability. The total score is 30 points. A score of 25 points or less indicated impaired cognitive function. For patients with less than12 years of education, one point was added to the total score.

Trial Locations

Locations (1)

Mansoura University Hospital; 🇪🇬 Mansoura, Egypt