Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes
- Conditions
- Type 2 Diabetes Mellitus
- Interventions
- Other: Aerobic Exercise Training
- Registration Number
- NCT01176578
- Lead Sponsor
- Baltimore VA Medical Center
- Brief Summary
The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 70
- Age 50-80
- Non-smoker
- If woman, postmenopausal >1 year
- History of heart disease or stroke
- Cancer
- Poorly controlled hypertension or dyslipidemia
- Kidney or Liver diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description IGT Aerobic Exercise Training Impaired Glucose Tolerance NGT Aerobic Exercise Training Normal Glucose Tolerance T2DM Aerobic Exercise Training Type 2 Diabetes Mellitus
- Primary Outcome Measures
Name Time Method Endothelial progenitor cell number 6-month Skeletal muscle capillarization 6-month
- Secondary Outcome Measures
Name Time Method Cardiorespiratory Fitness 6-month
Trial Locations
- Locations (1)
Baltimore VA Medical Center
🇺🇸Baltimore, Maryland, United States