Effects of aerobic and resistance exercise training on the heart performance and its relationship to genetic alteration in diabetic patients - randomized controlled clinical trial
Not Applicable
- Conditions
- Diabetes Mellitus type IIC18.452.394.750.149
- Registration Number
- RBR-492q8z
- Lead Sponsor
- niversidade Federal de São Carlos
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Volunteers of both genders between 30-65 years;Clinical diagnosis of type 2 diabetes, according to the American Diabetes Association;
Clinically stable;
Non-practicing physical activity in the last six months, with sort of sedentary, according to the American Heart Association (VO2max: 30.2 ± 4 3 ml/kg/min-1).
Exclusion Criteria
Smokers, elitist, in the presence of any diseases of the respiratory system and skeletal muscle, active inflammatory disease, acute or chronic, and evidence of myocardial ischemia and / or cardiovascular pathologies to clinical and / or exercise test.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method It is expected improved glycemic control, which will be checked by glycated hemoglobin. It is expected to decrease between pre and post training of approximately 1%. These results are expected after a 3-month intervention period.<br><br>To assess this outcome biochemical tests involving assessment of glycated hemoglobin, fasting glucose will be performed.<br><br>Main results<br>(1) demonstrated that a 12-week supervised, individualized, and personalized CART significantly improved (2) glycemic control, (3) body composition, (4) peak VO2,<br>and (4) muscular strength. Additionally, peak VO2 was correlated with HbA1c. <br>;The primary outcome to evaluate the values of Circulatory power and ventilatory power indices in patients with DM after a short period of combined training exercise program.
- Secondary Outcome Measures
Name Time Method Improvement of physical capacity, which is measured by oxygen consumption (peak VO2).<br>It is expected after the training period an improvement of cardiorespiratory fitness which will be verified by the maximal oxygen uptake for that cardiopulmonary test will be performed.<br>It is expected an increase of 1.2 ml / kg / min. after the combined physical activity program;The secondary outcome to evaluate the values of VE/VCO2 slope and the linear relationship between oxygen uptake and minute ventilation - OUES after exercise program intervention.