Effects of exercise training on cardiovascular and autonomic function among renal transplant recipients

Not Applicable

• Conditions: Z94.0; N18.5; G99.0; Kidney transplant status; Chronic kidney disease, stage 5; Autonomic neuropathy in endocrine and metabolic diseases

• Registration Number: DRKS00004287
• Lead Sponsor: Aristotle University of Thessaloniki

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2012-04-26
• Study Start: 2012-08-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

Sedentary, non-smokers, having received their transplant at least a year previously with stable transplant function.
Moreover, normotensive, aged between 18 to 60 years, both male and females, healthy sedentary nonsmokers volunteers are recruited.

Exclusion Criteria

Patients with unstable hypertension, diabetes mellitus, amyloidosis, congestive heart failure, recent myocardial infarction, unstable angina or musculoskeletal abnormality, who are using drugs that modify autonomic nervous system, as ß-blockers are excluded

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Baroreflex sensitivity is assessed at baseline and after 6 month noninvasively, using The Task Force Monitor 3040i device (CNSystem, Graz, Austria) <br>24-h electrocardiogram monitoring for arrhythmias detection and heart rate variability analysis is assessed at baseline and after 6 month noninvasively, using the Burdick Vision Holter System from Cardiac Science (Bothell, Washington, USA)

Secondary Outcome Measures

Name	Time	Method
Cardiorespiratory fitness is assessed at baseline and after 6 months using a symptom-limited cardiopulmonary exercise testing, under continuous ECG monitoring, on a treadmill (Trackmaster TM-400, Carollton TX, USA) using the Bruce protocol.