Hangzhou Hospital Staff Cohort

Active, not recruiting

• Conditions: Diabetes Mellitus; Cardiovascular Diseases; Metabolic Syndrome

• Registration Number: NCT04910321
• Lead Sponsor: Westlake University

Brief Summary

The Hangzhou Hospital Staff Cohort (HHSC) is a prospective cohort study among staffs from three hospitals located in Hangzhou, China, including the Hangzhou First People's Hospital, Hangzhou Women's Hospital, and Hangzhou Red Cross Hospital. Participants recruitment and baseline survey including anthropometric, lifestyle and clinical measurement, as well as biological samples collection are initiated in January 2021. Recruited hospital staff are followed up every year during the medical examination organized by their employer. The primary aim of the HHSC study is to investigate the prospective associations of diet, physical activities, sleep, and other lifestyle factors with the long-term metabolic health of the hospital staffs. The secondary aim of the HHSC study is to integrate multi-omics data including genomics, metabolomics, proteomics and microbiome by a machine learning algorithm, to probe into the complex mediating roles of gene, metabolism and gut microbiota linking lifestyle factors with metabolic health.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-30
• Study First Submitted: 2021-04-05
• Study First Submitted QC: 2021-05-26
• Study First Posted: 2021-06-02
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-26
• Last Update Posted: 2022-04-28
• Primary Completion: 2029-12-31
• Study Completion: 2029-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

• Participants aged 18 years or older
• Serving staffs of designated hospitals

Exclusion Criteria

• Participants with cancer
• Participants with other serious medical disorders

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L	9 years after enrollment	Fasting blood glucose is measured every year during follow-up

Secondary Outcome Measures

Name	Time	Method
Change of body mass index	Change from baseline at 9 years	Participants' body weight and height was measured to calculate body mass index every year during follow-up

Trial Locations

Locations (1)

Hangzhou First People's Hospital; 🇨🇳 Hangzhou, Zhejiang, China