Can Therapy Alter CNS Processing of Chronic Pain: A Longitudinal Study

Not Applicable

• Conditions: Chronic Pain
• Interventions: Behavioral: Therapeutic Interactive Voice Response; Behavioral: NO TIVR; Behavioral: Group Cognitive Behavioral Therapy; Behavioral: Pain Education

• Registration Number: NCT01794988
• Lead Sponsor: University of Vermont

Brief Summary

The purpose of this study is to investigate whether a psycho-therapeutic approach, group Cognitive Behavioral Therapy (CBT) plus a relapse prevention program, Therapeutic Interactive Voice Response (TIVR), modifies the dysfunctional sensory, emotional, and cognitive neural circuitry associated with chronic pain.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-07
• Status Verified: 2013-02
• Study First Submitted: 2013-02-15
• Study First Submitted QC: 2013-02-19
• Last Update Submitted: 2013-02-19
• Study First Posted: 2013-02-20
• Last Update Posted: 2013-02-20
• Primary Completion: 2015-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• At least 12 months of muscular-skeletal, non-neuropathic pain

Read More

Exclusion Criteria

• Malignancy causing or influencing chronic pain
• Radiation or chemotherapy, or metastatic cancer of any type
• Reflex Sympathetic Dystrophy (RSD) and/or neuropathic pain
• Neurological disorders such as epilepsy or stroke, or other medical conditions
• Psychiatric disorders
• Opioid medication use for pain management
• Past year history of illicit drug use that can result in altered cognition
• Pregnancy
• Exceeding weight limit of the MRI scanner
• Incompatible implants due to MRI safety
• Awaiting pain related surgical procedure
• Involved in pain-related litigation

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Therapeutic Interactive Voice Response	Therapeutic Interactive Voice Response	Four months of therapeutic interactive voice response (TIVR).
No TIVR	NO TIVR	Control - no intervention
Group Cognitive Behavioral Therapy	Group Cognitive Behavioral Therapy	Participants will undergo 11 weeks of group cognitive behavioral therapy (CBT) and a pre- and post-intervention MRI brain scan.
Pain Education	Pain Education	Participants will receive 11 weeks of pain education and a pre- and post-intervention MRI brain scan.

Primary Outcome Measures

Name	Time	Method
Pain	Seven Months

Trial Locations

Locations (1)

University of Vermont College of Medicine, MindBody Medicine Clinic; 🇺🇸 Burlington, Vermont, United States