Cognitive Training in Heart Failure Study (CogTrain-HF)
- Conditions
- Congestive Heart FailureCognitive Impairment
- Interventions
- Behavioral: Test of general knowledgeBehavioral: Cognitive training
- Registration Number
- NCT02415517
- Lead Sponsor
- Universität des Saarlandes
- Brief Summary
The daily routine in clinical settings often showed cognitive impairments in patients with congestive heart failure, particularly in terms of executive functions, episodic memory, perceptual speed and attention. It is assumed that cognitive impairments in patients with congestive heart failure may lead to deficits in medication-adherence and self-care abilities, resulting in increased healthcare costs. Recent studies reported performance improvements after cognitive training that transferred to new, untrained tasks and abilities in healthy subjects across a wide range of ages. This study investigates the effects of cognitive training in patients with congestive heart failure.
- Detailed Description
Cognitive functions of patients with congestive heart failure (NYHA II-III) before (pretest) and after (posttest) cognitive-training intervention are investigated. Changes in cognitive functions are compared to changes in two control groups: 1) age and gender matched active control group 2) age and gender matched passive waiting list control group.
The neuropsychological test battery applied at pretest and posttest includes measures of episodic memory, working memory, short-term memory, executive functions, perceptual speed and intelligence. In addition, the investigators apply standardized questionnaires of self-assessed quality of life, cognitive functioning in daily life, selfcare, and psychological well-being (depression, anxiety and personality). Relevant physiological data such as ejection fraction, heartrate, N-terminal pro brain natriuretic peptide (NT-pro-BNP) as well as drug blood level are recorded.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 107
- Congestive heart failure
- NYHA II-III
- Psychosis
- Dementia
- Major depression
- Reanimation (<3month)
- Patients with assist device system
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Active control group Test of general knowledge Intervention: Test of general knowledge Experimental group Cognitive training Intervention: Cognitive Training
- Primary Outcome Measures
Name Time Method Training effects 3 weeks Improvement in performance in the last trainingssession compared with the performance in the first trainingssession. Performance will be assessed by computesoftware.
- Secondary Outcome Measures
Name Time Method Transfer effects 5 weeks Transfer effects are measured by comparing cognitive functions in patients with congestive heart failure before and after cognitive training. Cognitive functions will be assessed by different paper-and-pencil tests and computerbased tests.
Changes in quality of life and psychological well-being 5 weeks Changes in quality of life and psychological well-being as the result of cognitive training measured by psychological questionnaires and tests.
Long-term benefits of cognitive training in patients with congestive heart failure. 6 month Follow-up assessment by 6 months after training. Long-term benefits will be measured by different paper-and-pencil tests and computerbased tests as well as psychological questionnaires and tests.
Compliance with medication 5 weeks Compliance with medication measured as serum level of medication and heart failure-specific self-care duties.
Trial Locations
- Locations (2)
Department of Educational Science, Saarland University
🇩🇪Frankfurt am Main, Hessen, Germany
Clinic for Internal Medicine, Cardioloy, Angioloy, and Internal Intensive Care Medicine, Saarland University Hospital
🇩🇪Homburg, Saarland, Germany