Cognitive Intervention to Improve Memory in Heart Failure Patients

Indiana University2 个研究点分布在 1 个国家目标入组 276 人2017年2月22日

概览

阶段: 不适用
干预措施: 未指定
疾病 / 适应症: Heart Failure NYHA Class II
发起方: Indiana University
入组人数: 276
试验地点: 2
主要终点: Change in delayed recall memory as measured by Hopkins Verbal Learning Test
状态: 已完成
最后更新: 3年前

Cognitive Intervention to Improve Memory in Heart Failure patients

A three arm randomized controlled trial of 276 heart failure patients.

注册库

clinicaltrials.gov

开始日期

2017年2月22日

结束日期

2021年9月30日

最后更新

3年前

研究类型

Interventional

研究设计

Factorial

性别

All

发起方

责任方

Principal Investigator

主要研究者

Susan Pressler

Principal Investigator

Indiana University

•History of drug or alcohol abuse or major psychiatric diagnosis present before the heart failure diagnosis
•Alzheimer or other dementia diagnosis or central nervous system degenerative disorder
•Terminal cancer
•Patients with baseline Montreal Cognitive Assessment (MoCA) score of less than 19
•Supplement Eligibility: First 144 patients randomized in the parent trial.

Change in delayed recall memory as measured by Hopkins Verbal Learning Test

时间窗: At 8 months

Change in delayed recall memory as measured by Hopkins Verbal Learning Test

Change in serum brain derived neurotrophic factor ( BDNF) Level

时间窗: At 8 months

Co-Primary Outcome

Change in working memory as measured by CogState One Back Accuracy Task(At 8 months)
Change in health-related quality of life as measured by Minnesota Living with Heart Failure Questionnaire(At 8 months)
Cost-effectiveness of the Brain HQ training intervention as measured by calculating the Incremental cost effectiveness ratios (ICERs) using medical services costs(At 8 months)
Change in instrumental activities of daily living as measured by Everyday Problems Test(At 8 months)