Effectiveness of Preoxygenation With Positive Airway Pressure in Non-obese Healthy Patient: a Comparison of the Supine and 25° Head up Position
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Intubation;Difficult
- Sponsor
- B.P. Koirala Institute of Health Sciences
- Enrollment
- 60
- Primary Endpoint
- non-hypoxic apnoeic period (time to fall SpO2 to 92%)
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Several techniques such as positive airway pressure and head-up tilt during preoxygenation have shown to prolong non-hypoxic apnea period compared to conventional technique. However, uniform recommendations have not yet been made. Therefore, in the present study the investigators attempted to find out the effect of combination of 5 cmH2O CPAP and 25° head up position during preoxygenation.
Detailed Description
In this study 60 non-obese healthy adult patients were divided into three groups; Group C receiving preoxygenation in conventional technique, Group S receiving preoxygenation with 5 cmH2O CPAP and Group H receiving preoxygenation in 25° head-up position with 5 cmH2O CPAP. After 3 min of preoxygenation, anesthesia was induced and trachea intubated. After confirming the tracheal intubation by direct visualization, all patients were left apneic in supine position with the tracheal tube exposed to atmosphere till the SpO2 dropped to 92%. The primary outcome compared between the groups was the non-hypoxic apnoeic period (time to fall SpO2 to 92%).
Investigators
Yogesh Dhakal
Assistant Professor, Department of Anaesthesiology and Critical Care
B.P. Koirala Institute of Health Sciences
Eligibility Criteria
Inclusion Criteria
- •adult patients of ASA physical status I and II undergoing surgery under general anaesthesia
Exclusion Criteria
- •anticipated difficult mask ventilation/ intubation
- •individuals with significant cardiorespiratory or cerebrovascular disease
- •pregnant ladies
- •patient with history of epilepsy
- •body mass index \>25 kg/m2
- •hemoglobin \<8 gm/dL
- •patients who were non-ambulant for \>24 h, having SpO2 \< 97% while breathing in room air
- •phobia to facemask.
Outcomes
Primary Outcomes
non-hypoxic apnoeic period (time to fall SpO2 to 92%)
Time Frame: 2 hours
After 3 min of preoxygenation, anesthesia was induced and trachea intubated. After confirming the tracheal intubation by direct visualization, all patients were left apneic in supine position with the tracheal tube exposed to atmosphere till the SpO2 dropped to 92%.
Secondary Outcomes
- Comparison of PaCO2 at different time points(2 hours)
- Comparison of pH at different time points(2 hours)
- Comparison of PaO2 at different time points(2 hours)