CTRI/2023/08/057007尚未招募Unknown
Effect of Bupropion on second generation antipsychotic induced weight gain and Melanocyte stimulating hormone (MSH) in patients with schizophrenia and its relationship with cognitive symptoms- An open label study. - NI
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •In-patients satisfying the ICD-11 DCR criteria for schizophrenia.
- •First episode schizophrenia (2years)
- •Age 18-50yrs of both sexes.
- •BMI greater than or equal to 25 kg/m2
- •CDSS score <6 to rule out secondary negative symptoms.
- •Those who give written informed consent for participating in the study.
排除标准
- •Any other drug(except for Antipsychotics) that can cause weight gain.
- •Patients on 1st generation antipsychotics and or on 1st generation depot antipsychotics.
- •Co-morbid endocrine and/or cardiovascular conditions.
- •Any other major co-morbid psychiatric diagnosis and substance dependence excluding nicotine and caffeine.
- •Known hypersensitivity to Tab. Bupropion or any of its components.
- •Deranged liver function test ( ALT greater than/equal to 180 IU/L and/or AST greater than/equal to 140 IU/L)
- •Significant current/past medical or neurological illness including severe hepatic disease and history of severe head injury.
- •Patients currently receiving ECT.
- •Treatment resistant schizophrenia patients or patients on clozapine.
- •History of suicidality (intent/attempt)
- •QTc interval greater than/equal to 450ms in males and greater than/equal to 470ms in females on Electrocardiogram (ECG).
研究者
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