Role of adrenaline in the inflammatory response in people with diabetes mellitus type 1, and healthy individuals

Recruiting

• Conditions: Adrenaline induced inflammation; 10012653; inflammation of the whole body caused by the stress hormone adrenaline; 10003216; 10082206

• Registration Number: NL-OMON53203
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Ability to provide written informed consent Body-Mass Index: 19-30 kg/m2 Age >=16 years, <= 75 years Blood pressure: <140/90 mmHg Non-smoking Electrocardiogram not showing any serious arrythmia*s (PVC*s and PAC*s accepted)

Exclusion Criteria

Any event of cardiovascular disease in the past 5 years (e.g. myocardial infarction, stroke, heart failure, symptomatic peripheral arterial disease) Pregnancy or breastfeeding or unwillingness to undertake birth control measures Epilepsy, Current treatment with Alpha or beta blockers ( doxazosin, propranolol) History of panic disorders History of Arrhythmias Use of immune-modifying drugs or antibiotics Use of tricyclic antidepressants or MAO inhibitors Use of statins (e.g. stop statins >2 weeks before performing blood sampling. Any infection with systemic symptoms in past 2 weeks Vaccination in the past 2 weeks Proliferative retinopathy Nephropathy with an estimated glomerular filtration rate (by MDRD) *60ml/min/1.73m2 Overt impaired hypoglycaemic awareness assed by the Clarke Questionnaire 4 or highe

Study & Design

• Study Type: Interventional
• Study Design: Not specified