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临床试验/CTRI/2026/02/104810
CTRI/2026/02/104810尚未招募不适用

Role of Intraabdominal pressure Monitoring in prediction of Acute Kidney Injury in Burns Patients-An observational Prospective Cohort Study

AIIMS,New Delhi1 个研究点 分布在 1 个国家目标入组 155 人开始时间: 2026年3月10日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
155
试验地点
1

研究概览

简要总结

This is a prospective observational cohort study conducted in the Burns Intensive Care Unit of AIIMS New Delhi. The study aims to evaluate the role of intra abdominal pressure monitoring in the early prediction of acute kidney injury in adult burn patients. Acute kidney injury is a frequent and serious complication in major burns, and early detection is essential for improving outcomes. Intra abdominal pressure will be measured by the intravesical (bladder) method every 12 hours for five days or until ICU discharge. Renal function will be assessed daily using serum creatinine and urine output as per KDIGO 2012 criteria. The study will include adult patients aged 18 to 60 years with 20 to 60 percent total body surface area burns admitted within 48 hours of injury. Patients with pre existing chronic kidney disease, bladder pathology, recent abdominal surgery, pregnancy, or who decline consent will be excluded. Data will be analyzed to determine whether raised intra abdominal pressure predicts acute kidney injury, to identify threshold pressure values, and to evaluate associations with abdominal perfusion pressure, renal replacement therapy requirement, and clinical outcomes such as ICU length of stay, mechanical ventilation, and mortality. Findings may support integration of intra abdominal pressure monitoring into standard burn resuscitation protocols for early detection and prevention of renal complications.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Adult patients aged 18 to 60 years.
  • Thermal or scald burns involving 20–60% Total Body Surface Area (TBSA).
  • Admission to the Burn ICU within 48 hours of burn injury.
  • Presence of indwelling Foley’s catheter for urine output monitoring (as per standard care).
  • Provision of informed written consent by the patient or legally authorized representative.

排除标准

  • Pre-existing renal disease or history of chronic kidney disease (CKD) (baseline creatinine greater than 1.5 mg/dL or known abnormal renal ultrasound).
  • Pre-existing bladder pathology such as neurogenic bladder, vesicoureteral reflux, bladder outlet obstruction, or recent urological procedures.
  • Abdominal surgery within the past 7 days prior to enrollment.
  • Pregnant women.
  • Patients with electrical burns exceeding 60 percentage TBSA or associated crush injuries.
  • Patients who decline consent or withdraw participation.

研究者

发起方
AIIMS,New Delhi
申办方类型
Research institution
责任方
Principal Investigator
主要研究者

Dr Esther Lalneidiki

AIIMS,New Delhi

研究点 (1)

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