Evaluating the diagnostic value of coronary physiology combined with optical coherence tomography in identifying the culprit lesion in adults presenting with non-ST elevation myocardial infarction

Royal Prince Alfred Hospital0 sites50 target enrollmentSeptember 9, 2021

Overview

No summary available.

Registry

who.int

Start Date

September 9, 2021

End Date

TBD

Last Updated

4 years ago

Study Type

Interventional

Sex

All

Sponsor

•1\) Patient age greater than or equal to 18 years, willing and able to give consent
•2\) NSTEMI defined as appropriate rise and fall of troponin, with at least one value above the 99th percentile and absence of ST\-segment elevation, together with one of the following:
•Symptoms of myocardial ischemia
•New ischemic ECG changes
•Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischemic etiology

•1\) Cardiogenic shock, defined as systolic blood pressure \< 90mmHg, or need for inotropic support to maintain adequate blood pressure.
•2\) Previous MI
•3\) Previous coronary artery bypass grafting surgery or PCI
•4\) Glomerular filtration rate \< 30 mL/min/1\.73 m2
•5\) Contraindication to CMR
•6\) Contraindication to adenosine
•7\) Alternative explanation for troponin rise
•8\) Pregnancy
•9\) Excessive tortuosity of coronary vessels that precludes safe passage of pressure wire/OCT catheter
•10\) Ongoing symptoms/ischemia refractory to medical therapy, which necessitates urgent coronary angiography