Coronary Physiology and Imaging to Identify the Culprit Artery in Non-ST Elevation Myocardial Infarction: The CAPTURE-NSTEMI pilot study

Not Applicable

• Conditions: Coronary heart disease; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12621001204831
• Lead Sponsor: Royal Prince Alfred Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-09-09
• Last Update Posted: 20 September 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1) Patient age greater than or equal to 18 years, willing and able to give consent
2) NSTEMI defined as appropriate rise and fall of troponin, with at least one value above the 99th percentile and absence of ST-segment elevation, together with one of the following:
•Symptoms of myocardial ischemia
•New ischemic ECG changes
•Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischemic etiology

Exclusion Criteria

1) Cardiogenic shock, defined as systolic blood pressure < 90mmHg, or need for inotropic support to maintain adequate blood pressure.
2) Previous MI
3) Previous coronary artery bypass grafting surgery or PCI
4) Glomerular filtration rate < 30 mL/min/1.73 m2
5) Contraindication to CMR
6) Contraindication to adenosine
7) Alternative explanation for troponin rise
8) Pregnancy
9) Excessive tortuosity of coronary vessels that precludes safe passage of pressure wire/OCT catheter
10) Ongoing symptoms/ischemia refractory to medical therapy, which necessitates urgent coronary angiography

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in correct identification of infarct-related artery between ICA findings alone vs integrated OCT/coronary physiology approach. [Immediately after performance of OCT and coronary physiology assessment]

Secondary Outcome Measures

Name	Time	Method
Change in revascularization strategy after disclosure of OCT and coronary physiology results. This information will be collected at the time of the index procedure by the investigators, or at the time of the multidisciplinary heart team review if indicated. [During index procedure or at the time of the multidisciplinary heart team review if indicated. ];Change in revascularization strategy after disclosure of CMR results. This information will be collected at the time of the index procedure by the investigators, or at the time of the multidisciplinary heart team review if indicated. [During index procedure, or at the time of the multidisciplinary heart team review if indicated. ]