on-invasive validation of shear stress measurements in patients with coronary artery disease

Not Applicable

Recruiting

• Conditions: coronary artery disease; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12617001239358
• Lead Sponsor: MonashHeart

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-08-24
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

1) Age greater or equal to 18 years of age.
2) Able to provide informed consent
3) Undergoing (or due to undergo) invasive coronary angiography for clinical reasons

Exclusion Criteria

1) Chronic renal failure with eGFR < 30 ml/min
2) Previous coronary artery bypass surgery
3) Left ventricular ejective fraction < 50% or known regional wall motion abnormality on echocardiogram
4) Atrial fibrillation
6) Moderate or severe aortic stenosis or left ventricular outflow tract gradient
7) Decompensated heart failure
8) Severe asthma or resting bradycardia precluding use of adenosine
9) Unfavourable coronary anatomy that would prohibit safe intracoronary imaging
10) Women of childbearing age

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary aim of this study is to assess the sensitivity of CTCA to identify low (<10 dynes/cm2) ESS arterial segments, using intravascular ultrasound (IVUS)-derived measures as gold-standard. [Baseline]

Secondary Outcome Measures

Name	Time	Method
The secondary aim of this study is to assess whether there is a correlation between CTCA- and IVUS-defined ESS measurements.[Baseline]