Accuracy of coronary MR plaque imaging in patient with chronic kidney disease associated with coronary artery disease
Not Applicable
- Conditions
- D003327, D000083242, D000075222, D058729, D001018, D003920coronary artery disease, ischemic stroke, hypertension, peripheral arterial disease, diabetes mellitChronic kidney disease, Coronary artery disease, Diabetic Mellitus
- Registration Number
- JPRN-jRCT1052210075
- Lead Sponsor
- oguchi Teruo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 524
Inclusion Criteria
Patients with stage 3 or higher chronic kidney disease with an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m2 with suspected coronary artery disease or angina pectoris
Exclusion Criteria
Patients with suspected acute coronary syndrome
Patients who have had myocardial infarction within 3 months
Patients with contraindication for MRI examination
Patients undergoing hemodialysis or peritoneal dialysis
Patients with a resting pulse rate of 80 beats per minute or higher, or patients with chronic atrial fibrillation
Patients who cannot give their consent.
Patients who have difficulty in understanding the contents of this study and who are judged to be inappropriate by the physician in charge.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method A composite of death from coronary heart disease and all cause death, nonfatal myocardial infarction, ischemia-driven unplanned coronary intervention (percutaneous coronary intervention or coronary bypass surgery, or hospitalization for unstable angina pectoris)
- Secondary Outcome Measures
Name Time Method 1) Incidence of composite cardiovascular events after 144 weeks of research testing (long-term prognosis)<br>2) Cost-effectiveness analysis<br>3) Comparison of management status (prescription rate of secondary prevention drugs for coronary artery disease and attainment of control goals for blood pressure, lipids, and diabetes; additional imaging tests (myocardial SPECT and cardiac MRI); and PCI or coronary artery bypass) after cardiac MRI and conventional testing<br>4) Complication rate of coronary artery HIP in high-risk patients for primary prevention of coronary artery disease with a Suita score of 66 or higher (Plaque to Myocardium Ratio (PMR) value of 1.1 or higher, and coronary artery HIP complication rate of 1.3 or higher)