Validation of CT Angiography and/or Magnetic Resonance Imaging markers for characterization and quantification of atherosclerosis in the carotid arteries by comparison with surgical specimens.
- Conditions
- Atherosclerosis10003216
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 150
* Patients with cerebrovascular symptoms (TIA, minor stroke) in the last six months
* CTA of the carotid arteries (at the Erasmus Medical Center or referring centre) during the last 2
months (CTA is performed for clinical work-up)
* Scheduled endarterectomy of a carotid artery
* Signed informed consent
* At least 18 years old
* Patients who have a documented allergy to MRI contrast media are eligible for MRI, but will not
undergo a contrast-enhanced scan. Patients with a renal clearance (eGFR) <30 ml/minute are
eligible for MRI, but will not undergo contrast-enhanced MRI.
* Woman who are pregnant or lactating
* Patients who are hemodynamically unstable
* Having any physical or mental status that interferes with the informed consent procedure
* Not being able to remain lying down for at least 40-45 min (e.g. patients with unstable angina, dyspnea at rest, severe pain at rest, severe back pain)
* Contraindications for MRI (e.g. claustrophobia)
* Metal chip in the ocular bulb identified on X-ray (If a patient affirms to ever have had a metal chip in his eyeball an X-ray will be made to check if it is still present)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1) The accuracy of CT Angiography and/or MRI imaging markers of vessel lumen,<br /><br>arterial flow and plaque composition to characterize<br /><br>atherosclerotic plaque in the carotid arteries.<br /><br>2) The accuracy of CT Angiography and/or MRI to quantify plaque volume and the<br /><br>volume of the different plaque components.<br /><br>3) Determinants: blood flow parameters. Outcome: to link blood flow parameters<br /><br>to plaque composition and morphology</p><br>
- Secondary Outcome Measures
Name Time Method <p>na</p><br>