A Feasibility Study of a Low Tidal Volume Ventilation Strategy in One Lung Ventilation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Low Tidal Volume Ventilation
- Sponsor
- University of Dublin, Trinity College
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Radiological evidence of injury to the ventilated lung
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
A study of two ventilatory strategies for low tidal volume ventilation compared to a control group to elucidate if low tidal volumes of 3ml/kg or 4ml/kg were feasible for one lung ventilation.
Detailed Description
This study investigated the feasibility of low tidal volume ventilation for one lung ventilation. 45 patients were recruited - 15 patients in each of three groups, 3ml/kg, 4ml/kg or usual care. Outcomes studied were length of stay, 30 day mortality, unplanned ICU admission, evidence of respiratory failure or requirement for non-invasive ventilation, chest x-ray infiltrates and requirement for antibiotics.
Investigators
ignacio martin loeches
Consultant Intensivist
University of Dublin, Trinity College
Eligibility Criteria
Inclusion Criteria
- •ASA I-III lung resection surgery requiring one lung ventilation
Exclusion Criteria
- •ASA IV or above under 18 or over 80 years of age pregnancy previous lung lobectomy or pneumonectomy requirement for massive transfusion during the case BMI \> 35
Outcomes
Primary Outcomes
Radiological evidence of injury to the ventilated lung
Time Frame: post operatively up to 6 weeks post operatively
evidence of infiltrates in the non operative lung
unplanned ICU admission
Time Frame: up to 6 weeks post operatively
unplanned admission to the icu with respiratory issues
Requirement for non-invasive ventilation
Time Frame: up to 6 weeks post operatively
whether a patient in the trial requires niv for respiratory failure
Hospital acquired pneumonia
Time Frame: up to discharge at 6 weeks post operatively
pneumonia acquired in hospital
Secondary Outcomes
- length of hospital stay(until patient discharge at 6 weeks post operatively)
- length of icu stay(until patient discharge at 6 weeks post operatively)
- 30 day mortality(30 days post operatively)