Thermic & Lipemic Properties of Dietary Carbohydrates
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 试验地点
- 2
- 主要终点
- Respiratory Gas Exchange
研究概览
简要总结
The purpose of this study is to determine if consumption of meals containing carbohydrates with different glycemic index (a high glycemic index meal and a low glycemic index meal)have different effects on energy expenditure, type of metabolic fuels used for energy, blood lipids and lipoproteins, and sensations of hunger, fullness, and the hormones related to satiety.
详细描述
Little is known about the metabolic effects of chronic dieting and weight cycling in humans, but limited evidence suggests that fatty acid oxidation may be depressed leading to periodic elevation of circulating lipids associated with meal ingestion and preferential storage of fat in adipose tissue. With the traditional approach of restrictive dieting failing to result in permanent weight loss and, possibly producing abnormalities in lipid metabolism, it is important to evaluate alternative approaches to achieve a healthy body weight through improved metabolism. In this study the investigators will test the postprandial metabolic effects of standard mixed meals containing carbohydrates with high glycemic index and compare these effects to responses obtained with standard mixed meals, matched for protein and fat content but containing carbohydrates with low glycemic index.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 48 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Body mass index between 25 and 30 kg/m2
- •Having regular menses
- •Willing to refrain from restrictive dieting during the course of the study
排除标准
- •Pregnant or currently planning a pregnancy
- •Cigarette smoking
- •Taking medications to induce weight loss or change appetite
- •History of cardiovascular disease
- •History of metabolic disorders, including diabetes
结局指标
主要结局
Respiratory Gas Exchange
时间窗: 30 minutes before a standardized test meal and intermittently for 480 minutes following the meal.
Respiratory Gas Exchange will be measured using an automated metabolic cart. Gas analyzers and volumeter will be calibrated using manufacturer's procedures.
次要结局
- Plasma glucose(10 blood samples taken over a 480 minute period.)
- Circulating lipoproteins(4 blood samples taken over a 480 minute period)
- Subjective evaluation of appetite(16 timepoints measured over 600 minutes)
- Food consumption at a buffet-style meal(at 480 minutes following test meal)
- Body composition(measured the morning of the standard meal challenge)
- Serum insulin(10 blood samples taken over a 480 minute time period)
- Plasma leptin(10 blood samples taken over a 480 minute period)
- Plasma ghrelin(10 blood samples taken over a 480 minute time period)
- Cholecystokinin (CCK)(10 blood samples taken over a 480 minute time period)
- GLP-1(10 blood samples taken over a 480 minute time period)