Sugar Sweetened Beverages (SSB)- Effects on Metabolism

Not Applicable

Completed

• Conditions: Metabolism
• Interventions: Procedure: Soft drink consumption

• Registration Number: NCT01733563
• Lead Sponsor: University of Zurich

Brief Summary

The objective of this study is to investigate the impact of sugar sweetened beverages on the fat metabolism of healthy young men. It is well known that consumption of beverages sweetened with fructose is associated with different health risks such as type 2 diabetes. The present study has been designed to dissect differences in the metabolic pathways of fructose and glucose, but also metabolic adaptations during fructose, glucose and sucrose diets. During a period of seven weeks subjects will consume either fructose, glucose or sucrose sweetened beverages or continue their usual drinking habits. During these seven weeks there will be different metabolic investigations using stable isotope tracers. First, the rate of lipolysis and beta-oxidation will be determined. Second, the rates of fatty acid synthesis will be measured. During all examinations there will also be substrate- and energy-utilization measurements by indirect calorimetry, blood analysis and morphometric measurements. Based on the literature main hypotheses are: Fructose enhances de novo lipogenesis postprandially and also in the fasting state significantly more than glucose by enhanced expression of lipogenic enzymes. Fructose decreases beta oxidation via downregulation of oxidative enzymes.

Detailed Description

Not available

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study First Submitted: 2012-11-09
• Study First Submitted QC: 2012-11-26
• Study First Posted: 2012-11-27
• Study Start: 2013-04
• Status Verified: 2016-05
• Primary Completion: 2016-05
• Study Completion: 2016-05
• Last Update Submitted: 2016-05-10
• Last Update Posted: 2016-05-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 96

Inclusion Criteria

Not provided

Read More

Exclusion Criteria

Not provided

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
No change of eating habits	Soft drink consumption	No Soft drink consumption (no soft drink diet): Subjects do not change their eating habits during 7 weeks
sucrose sweetened beverage	Soft drink consumption	Soft drink consumption: Subjects have to drink a sucrose sweetened beverage (3x 200ml per day, 13.3g sucrose/100ml) during 7 weeks
fructose sweetened beverage	Soft drink consumption	Soft drink consumption: Subjects have to drink a fructose sweetened beverage (3x 200ml per day, 13.3g fructose/100ml) during 7 weeks
glucose sweetened beverage	Soft drink consumption	Soft drink consumption: Subjects have to drink a glucose sweetened beverage (3x 200ml per day, 13.3g glucose/100ml) during 7 weeks

Primary Outcome Measures

Name	Time	Method
Lipogenesis	After total 6 weeks dietary intervention	Measurement of lipogenesis is based on i. v. administration of stable isotope labelled acetate (1,2-13C-acetate). 13C incorporation into palmitate is quantified by mass-spectrometry. 13C incorporation correlates to the rate of fatty acid synthesis.

Secondary Outcome Measures

Name	Time	Method
Lipolysis	After total 6 weeks dietary intervention	Measurements using stable isotopes

Trial Locations

Locations (1)

University Hospital Zurich, Endocrinology and Diabetology; 🇨🇭 Zurich, ZH, Switzerland