Thyroid Gland Dysfunction and Vitamin D Polymorphism in Keratoconus

Completed

Brief Summary: This prospective study the thyroid gland dysfunction and vitamin D receptor polymorphism in keratoconus patients

Detailed Description: This is a prospective observational study in which blood samples are collected from keratoconus patients looking for thyroid dysfunction and vitamin D levels in the serum and assessing the Vitamin D receptor polymorphism in comparison to healthy control.

Recruitment & Eligibility

Inclusion Criteria

keratoconus patients without previously diagnosed thyroid disorder in comparison to healthy control without known systemic disease and with normal cornea who were selected from candidates of refractive surgery with normal topography

Exclusion Criteria

patients who could not provide informed consent or the necessary samples for any reason, patients with associated other ophthalmic pathologies or systemic disorders were excluded from the study

Arm && Interventions

Group	Intervention	Description
keratoconus group	ELISA,DNA extraction	group of keratoconus patients with no history of thyroid dysfunction
control group	ELISA,DNA extraction	group of subjects with healthy cornea

Primary Outcome Measures

Name	Time	Method
concentration of free T4	2 month	ng/dl
concentration of free T3	2month	pg/ml
concentration of TSH	2 month	milli-international units per liter
vitamin D receptor polymorphism	2 month	number of participant with vitamin D receptor polymorphism

Secondary Outcome Measures

Name	Time	Method
serum vit D	2 month	concentration of Serum 25 OH vitamin D (ng /ml)

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