Thyroid Gland Dysfunction and Vitamin D Polymorphism in Keratoconus
Completed
- Conditions
- Keratoconus
- Registration Number
- NCT05073601
- Lead Sponsor
- Mansoura University
- Brief Summary
This prospective study the thyroid gland dysfunction and vitamin D receptor polymorphism in keratoconus patients
- Detailed Description
This is a prospective observational study in which blood samples are collected from keratoconus patients looking for thyroid dysfunction and vitamin D levels in the serum and assessing the Vitamin D receptor polymorphism in comparison to healthy control.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 262
Inclusion Criteria
- keratoconus patients without previously diagnosed thyroid disorder in comparison to healthy control without known systemic disease and with normal cornea who were selected from candidates of refractive surgery with normal topography
Exclusion Criteria
- patients who could not provide informed consent or the necessary samples for any reason, patients with associated other ophthalmic pathologies or systemic disorders were excluded from the study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method concentration of free T3 2month pg/ml
concentration of TSH 2 month milli-international units per liter
vitamin D receptor polymorphism 2 month number of participant with vitamin D receptor polymorphism
concentration of free T4 2 month ng/dl
- Secondary Outcome Measures
Name Time Method serum vit D 2 month concentration of Serum 25 OH vitamin D (ng /ml)
Trial Locations
- Locations (1)
Eman Azmy
🇪🇬Mansoura, Dakahlia, Egypt
Eman Azmy🇪🇬Mansoura, Dakahlia, Egypt