Hepatitis A vaccination coverage amongst people with Chronic Liver Disease in England (HEALD): protocol for a retrospective cohort study
- Conditions
- People with chronic liver disease, including alcohol-related liver disease (ALD), chronic hepatitis B infection (CH-B), chronic hepatitis C infection (CH-C), and non-alcoholic fatty liver disease (NAFLD)Digestive System
- Registration Number
- ISRCTN11919759
- Lead Sponsor
- niversity of Oxford
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 1650
We will include adults registered in general practices within the RSC network, with a diagnosis of CLD, as defined by our ontology, within the period between the 1st January 2012 and 31st December 2022. The following inclusion criteria will be applied:
People registered in the RSC general practices, aged 18 years of age and older, with a diagnosis of CLD. Our ontology for CLD includes: Alcoholic liver disease (ALD), chronic hepatitis B (CH-B), chronic hepatitis C (CH-C), non-alcoholic fatty liver disease, Wilson´s Disease, haemochromatosis, autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC).
1. Patients with recorded contraindications to the Hep A vaccine (confirmed anaphylactic reaction to a previous dose of Hep A containing vaccine, or to any of its components).
2. Records of administration of post-infection or risk-of-infection immunoglobulins.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of doses of hepatitis A vaccination measured using patient records at a single time point
- Secondary Outcome Measures
Name Time Method There are no secondary outcome measures