Maladie d'Alzheimer et Troubles Locomoteurs : Caracterisation Des Anomalies Temporelles de la Marche et Etude Des Correlats Anatomo-cognitifs
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 912
- 试验地点
- 1
- 主要终点
- Stride-to-stride variability of stride time
研究概览
简要总结
The purpose of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).
详细描述
Although gait disorders are frequently associated with Alzheimer's disease (AD), few studies have focused on their characterization and mechanism. Exploring the associations of the gait characteristics - more particularly the gait variability - with the cognitive performance of AD patients on one hand, and with the morphological brain abnormalities on the other hand, could be useful to understanding the mechanisms of gait disorders in AD.
The main objective of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and moderate dementia stages).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥ 60 years
- •Able to walk without walking aid on 15 metres
- •Score of Mini-Mental Examination (MMSE) > 10
- •Written informed consent to participate in the study (or trustworthy person)
- •Being affiliated to a social security regime
- •Near visual acuity ≥ 2/10
- •Absence of severe depression (score in the 15-item Geriatric Depression Scale ≤ 10)
排除标准
- •Score of Mini-Mental Examination (MMSE) ≤ 10
- •Subject suffering from pre-existing impellent disturbances
- •History of cerebrovascular accident or other cerebro-spinal pathology
- •Poor workmanship of the written or oral French language
- •Refusal of subject to be informed on possible hanging bare anomaly during study
- •Use of walking aid
- •Acute medical or surgical disease in the past 3 months
- •Refusal to participate (or trustworthy person)
- •Contra-indication to the achievement of a Magnetic Resonance Imaging
- •Near visual acuity < 2/10
- •Presence of severe depression (score in the 15-item Geriatric Depression Scale > 10)
结局指标
主要结局
Stride-to-stride variability of stride time
时间窗: baseline
次要结局
未报告次要终点