Maladie d'Alzheimer et Maladies apparentées : Caractérisation Des Anomalies Cognitivo-motrices, et Des Effets Des médicaments Anti-démence et de la Vitamine D à Partir de la Mise en Place d'Une Base de données au CMRR du CHU d'Angers
Overview
- Phase
- N/A
- Intervention
- Drug intervention
- Conditions
- Alzheimer's Disease
- Sponsor
- University Hospital, Angers
- Enrollment
- 700
- Locations
- 1
- Primary Endpoint
- Spatiotemporal gait parameters
- Last Updated
- 15 years ago
Overview
Brief Summary
The purpose of this study is to compare characteristics of gait and balance measured among patients with Alzheimer's disease or related disorders separated into 3 groups according to the stage of disease (i.e., pre-dementia, mild and moderate dementia stages); to determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities; and to establish a database at Angers University Memory Centre.
Detailed Description
Although gait disorders are frequently associated with Alzheimer's disease and related disorders (ADRD), few studies have focused on cognitive motor effects of anti-dementia drugs and vitamin D. The objectives of this study are to * Compare characteristics of gait and balance measured among patients with ADRD separated into 3 groups according to stages of disease (i.e., pre-dementia, mild and moderate dementia stages) * To determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities * To determine whether motor abnormalities could be associated with cognitive impairments, specifically executive dysfunctions * To establish a database at Angers University Memory Center.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All elderly patients from the University Memory Center of Angers University Hospital.
- •Able to walk without any walking aid on 15 meters
- •Mini-Mental Status Examination score \> 10
- •Being affiliated to a social security regime
Exclusion Criteria
- •Mini-Mental Status Examination score ≤ 10
- •Subject suffering from pre-existing impellent disturbances
- •History of cerebrovascular accident or other cerebro-spinal pathology
- •Poor workmanship of the written or oral French language
- •Use of walking aid such as walking frame with wheels or tricycle.
- •Acute medical or surgical disease in the past 3 months
- •Refusal to participate (or trustworthy person)
- •Near visual acuity \< 2/10
Arms & Interventions
Group 1
Patients with Mild Cognitive Impairment
Intervention: Drug intervention
Group 2
Patients with Mild Alzheimer's disease or related disorders
Intervention: Drug intervention
Group 3
Patients with Moderate Alzheimer's disease or related disorders
Intervention: Drug intervention
Outcomes
Primary Outcomes
Spatiotemporal gait parameters
Time Frame: baseline