Maladie d'Alzheimer et Maladies apparentées : Caractérisation Des Anomalies Cognitivo-motrices, et Des Effets Des médicaments Anti-démence et de la Vitamine D à Partir de la Mise en Place d'Une Base de données au CMRR du CHU d'Angers
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- Spatiotemporal gait parameters
研究概览
简要总结
The purpose of this study is to compare characteristics of gait and balance measured among patients with Alzheimer's disease or related disorders separated into 3 groups according to the stage of disease (i.e., pre-dementia, mild and moderate dementia stages); to determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities; and to establish a database at Angers University Memory Centre.
详细描述
Although gait disorders are frequently associated with Alzheimer's disease and related disorders (ADRD), few studies have focused on cognitive motor effects of anti-dementia drugs and vitamin D.
The objectives of this study are to
- Compare characteristics of gait and balance measured among patients with ADRD separated into 3 groups according to stages of disease (i.e., pre-dementia, mild and moderate dementia stages)
- To determine the effects of anti-dementia drugs and vitamin D on cognitive motor abnormalities
- To determine whether motor abnormalities could be associated with cognitive impairments, specifically executive dysfunctions
- To establish a database at Angers University Memory Center.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All elderly patients from the University Memory Center of Angers University Hospital.
- •Able to walk without any walking aid on 15 meters
- •Mini-Mental Status Examination score > 10
- •Being affiliated to a social security regime
排除标准
- •Mini-Mental Status Examination score ≤ 10
- •Subject suffering from pre-existing impellent disturbances
- •History of cerebrovascular accident or other cerebro-spinal pathology
- •Poor workmanship of the written or oral French language
- •Use of walking aid such as walking frame with wheels or tricycle.
- •Acute medical or surgical disease in the past 3 months
- •Refusal to participate (or trustworthy person)
- •Near visual acuity < 2/10
研究组 & 干预措施
Group 1
Patients with Mild Cognitive Impairment
干预措施: Drug intervention (Drug)
Group 2
Patients with Mild Alzheimer's disease or related disorders
干预措施: Drug intervention (Drug)
Group 3
Patients with Moderate Alzheimer's disease or related disorders
干预措施: Drug intervention (Drug)
结局指标
主要结局
Spatiotemporal gait parameters
时间窗: baseline
次要结局
未报告次要终点