CTIS2024-511679-14-00Active, not recruitingPhase 1
Improving outcome in subarachnoid hemorrhage with nadroparin
Conditions
Trial Snapshot
- Phase
- Phase 1
- Status
- Active, not recruiting
- Sponsor
- Amsterdam UMC Stichting
- Enrollment
- 100
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional clinical trial of medicinal product
Eligibility Criteria
- Ages
- 18 to 65+ (—)
- Sex
- All
Inclusion Criteria
- •SAH confirmed by CT or lumbar puncture with the causative aneurysm confirmed by CT-A and/or DSA, Coiling of the causative aneurysm within 72 hours of initial SAH, Informed consent before the first scheduled administration of the study medicine, Adult age (=18 years)
Exclusion Criteria
- •Stent-assisted coiling, Use of anticoagulant or dual antiplatelet medication post-coiling for other reasons, Incomplete aneurysm occlusion/partial coiling, Intraparenchymal hemorrhage, Pregnancy, Contra-indications for LMWH: oPrevious history of history of heparin-induced thrombocytopenia o(Suspicion of) active arterial or venous bleeding oPrevious history of hemorrhagic diathesis due to coagulation disorders (with the ex-ception of disseminated intravascular coagulation) oSevere hypertension: uncontrolled hypertension with a MAP > 135mmHg oPrevious history of hypertensive or diabetic retinopathy oPrevious history of active infectious endocarditis oSevere renal impairment (creatinine clearance <30 mL / min), No proficiency of Dutch or English language, Proven and active COVID-19 infection
Investigators
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