Changes in Brain Glucose Metabolism as Evaluated by F-18 FDG PET/CT in Autistic Patients after Transcranial Direct Current Stimulation, Non Randomized Controlled trial

Phase 2

• Conditions: Autism Spectrum Disorder; Autism Spectrum Disorder, ASD, Transcranial Direct Current Stimulation, F-18 FDG PET-CT

• Registration Number: TCTR20210705005
• Lead Sponsor: Research and service institute for autism

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-07-05
• Study Completion: 2021-07-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

(a) mild to moderate autistic symptoms (CARS score 30-36.5) which could stay still in the scanner;
(b) aged between 15 and 30;
(c) the caregiver consents to participate in the research and can follow up the stimulation results;
(d) a healthy volunteer aged between 15 and 30.

Exclusion Criteria

(a) wound or skin abrasion at the area under electrode; (b) on metallic device; (c) skull defect; (d) severe neurological disorders such as brain tumor, intracranial infection; (e) drug abuse; (f) uncooperative parents and caregivers; (f) uncontrollable epilepsy; (g) use of herbal remedies and other alternative therapies such as craniosacral manipulation or hyperbaric oxygen therapy; and (h) claustrophobia

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
brain metabolism of the autistic patient at 1 day before treatment F-18 FDG PET/CT scan,ATEC score at day 5 and day 14 Questionnaire

Secondary Outcome Measures

Name	Time	Method
change in brain metabolism after 5 sessions of anodal tDCS at 1 week before treatment and immediately after treatment F-18 FDG PET/CT scan, correlation between ATEC social subscale changed and regional brain glucose metabolism changed immediately after treatment F-18 FDG PET/CT scan