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临床试验/NCT02759523
NCT02759523已完成不适用

Neural Mechanisms Underlying Children's Responses to Food Portion Size and Energy Density

Penn State University0 个研究点目标入组 108 人开始时间: 2013年7月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
108
主要终点
fMRI blood oxygen level dependent (BOLD) response to food portion size and energy density

研究概览

简要总结

Increased portion sizes of foods high in energy density (calories per gram of food) have been implicated in the obesity epidemic. Numerous studies show that children and adults eat more from larger portions of food than they do from smaller portions, a response known as the portion size effect. Despite the robust and consistent nature of these findings, the mechanisms underlying the portion size effect are not known. The long-term goal of this research is to identify the neural mechanisms involved in the portion size effect so that this information can be used to develop effective weight-management strategies. Differences in neural response to food cues, as demonstrated by functional magnetic resonance imaging (fMRI), can help clarify the factors that determine susceptibility to large portions. The goal of this study is to identify brain regions activated in response to portion size and energy density and relate these neural responses to laboratory eating behaviors in children.

The investigators hypothesize that high relative to low energy density food images will be associated with increased activation in regions of the brain involved in reward- and sensory- processing and that large relative to small portion size food images will be associated with increased activation in regions of the brain involved in cognitive control. In addition, the investigators hypothesize that these brain responses will influence the relationship between portion size served and energy intake at laboratory meals.

详细描述

What this study will add to the literature: The response to food images that vary by portion size using fMRI has not been previously reported. Furthermore, how the brain response to food portion size and energy density is related to energy intake has not been previously reported. The goal of this study is to identify brain regions activated in response to portion size and energy density and relate these neural responses to laboratory eating behaviors in children.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Other

入排标准

年龄范围
7 Years 至 10 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Right-handedness
  • English as native language
  • Reading at /above grade level
  • Not claustrophobic
  • Generally healthy

排除标准

  • Left-handedness
  • Metal in or on the body that cannot be removed
  • Claustrophobic
  • Medication usage that could alter brain activity
  • Medical disorder that may impact comfort in scanner
  • Food allergies

结局指标

主要结局

fMRI blood oxygen level dependent (BOLD) response to food portion size and energy density

时间窗: Collected at fMRI scan (1 of 1) at week 5

Whole-brain response to food images that varied at 2 levels of portion size and 2 levels of energy density

Energy intake

时间窗: Collected at week 1, 2, 3, and 4

Energy intake (kcal and grams) of foods consumed ad libitum at each laboratory test-meal in response to 4 conditions of portion sizes (100% reference, 133%, 167%, 200%).

次要结局

  • Region of Interest (ROI)-response to food portion size and energy density(Collected at fMRI scan (1 of 1) at week 5)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Kathleen Loralee Keller

Director, Metabolic Kitchen & Children's Eating Behavior Lab

Penn State University

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