The effect of magnesium sulfate in reducing the pain of knee replacement surgery
Phase 3
Completed
- Conditions
- Total knee arthroplasty.Osteoarthritis of knee
- Registration Number
- IRCT20161204031229N6
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
All volunteers for Total knee arthroplasty
Exclusion Criteria
Diabetes
Renal Disorder
Hepatic Disorder
Consumption of Calcium Blocker agents
Consumption of Magnesium supplements before the study
Consumption of Magnesium supplements during the study in the last month
magnesium level more than 2.8
Pregnancy
Lactation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluate the patient's pain. Timepoint: Immediately after surgery, 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Use visual analogue scale and numerical rating scale.;Serum level of magnesium sulfate. Timepoint: Daily. Method of measurement: Laboratory methods.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie magnesium sulfate's analgesic effects in total knee arthroplasty postoperative pain?
How does magnesium sulfate compare to NSAIDs in reducing opioid consumption after TKA for knee osteoarthritis?
What are the primary clinical endpoints of the IRCT20161204031229N6 phase III trial on magnesium sulfate in TKA?
Which biomarkers correlate with reduced postoperative pain in knee osteoarthritis patients receiving magnesium sulfate?
What combination therapies with magnesium sulfate enhance pain relief in total knee arthroplasty compared to monotherapy?